Liu Ting, Kan Xue-Feng, Ma Charlie, Chen Li-Li, Cheng Tian-Tian, Zou Zhen-Wei, Li Yong, Cao Feng-Jun, Zhang Wen-Jie, Yao Jing, Li Pin-Dong
1 Department of Infectious Diseases, Institute of Infection and Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
2 Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tumour Biol. 2017 Jun;39(6):1010428317700410. doi: 10.1177/1010428317700410.
Glutathione peroxidase 2 has important role of tumor progression in lots of carcinomas, yet little is known about the prognosis of glutathione peroxidase 2 in hepatocellular carcinoma. Glutathione peroxidase 2 expression was assessed by immunohistochemistry in hepatocellular carcinoma tissues. The association between glutathione peroxidase 2 expression with clinicopathological/prognostic value was examined. Glutathione peroxidase 2 overexpression was correlated with alpha-fetoprotein level, larger tumor, BCLC stage, and tumor recurrence. Kaplan-Meier analysis showed that glutathione peroxidase 2 was an independent predictor for overall survival and time to recurrence. glutathione peroxidase 2 overexpression was correlated with poor prognosis in patient subgroups stratified by tumor size, differentiation, tumor-node-metastasis, and BCLC stage. Moreover, stratified analysis showed that tumor-node-metastasis stage-I patients with high glutathione peroxidase 2 expression had poor prognosis than those with low glutathione peroxidase 2 expression. Additionally, combination of glutathione peroxidase 2 and serum alpha-fetoprotein was correlated with prognosis in hepatocellular carcinoma. In conclusion, glutathione peroxidase 2 overexpression contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients.
谷胱甘肽过氧化物酶2在许多癌症的肿瘤进展中起着重要作用，但关于谷胱甘肽过氧化物酶2在肝细胞癌中的预后情况却知之甚少。通过免疫组织化学方法评估肝细胞癌组织中谷胱甘肽过氧化物酶2的表达情况。检测谷胱甘肽过氧化物酶2表达与临床病理/预后价值之间的关联。谷胱甘肽过氧化物酶2的过表达与甲胎蛋白水平、较大肿瘤、BCLC分期及肿瘤复发相关。Kaplan-Meier分析表明，谷胱甘肽过氧化物酶2是总生存期和复发时间的独立预测指标。在按肿瘤大小、分化程度、肿瘤-淋巴结-转移情况及BCLC分期分层的患者亚组中，谷胱甘肽过氧化物酶2过表达与预后不良相关。此外，分层分析显示，谷胱甘肽过氧化物酶2高表达的肿瘤-淋巴结-转移I期患者比谷胱甘肽过氧化物酶2低表达的患者预后更差。另外，谷胱甘肽过氧化物酶2与血清甲胎蛋白的联合检测与肝细胞癌的预后相关。总之，谷胱甘肽过氧化物酶2过表达导致肝细胞癌患者预后不良，并有助于识别高危肝细胞癌患者。
