Department of Histology and Cell Pathology in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.
Department of Pharmacy, School of Medicine, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Int J Mol Sci. 2023 Sep 27;24(19):14650. doi: 10.3390/ijms241914650.
Glutathione peroxidase 2 (Gpx-2) is a selenoenzyme with antioxidant capabilities that may play a role in cancer development. Hence, we investigated the immunohistochemical expression of Gpx-2 protein in colon adenocarcinoma samples derived from patients with colon adenocarcinoma who did not receive any form of treatment prior to the surgical procedure. The associations between the immunohistochemical expression of Gpx-2 and clinical parameters were analysed using the Chi test and Fisher's exact test. A Kaplan-Meier analysis and the log-rank test were used to verify the relationship between the intensity of Gpx-2 expression and the 5-year survival rate of patients. In total, 101 (80.80%) samples had strong Gpx-2 protein expression and 24 (19.20%) samples were characterized with low expression. The high expression of Gpx-2 was correlated with the histological grade of the tumour ( < 0.001), PCNA immunohistochemical expression ( < 0.001), depth of invasion ( = 0.001) and angioinvasion ( < 0.001). We can conclude that high expression of Gpx-2 is correlated with reduced survival of colon adenocarcinoma patients (log-rank, < 0.001).
谷胱甘肽过氧化物酶 2（Gpx-2）是一种具有抗氧化能力的硒酶，可能在癌症发展中发挥作用。因此，我们研究了未接受任何治疗形式的结肠癌患者的结肠癌腺癌样本中 Gpx-2 蛋白的免疫组织化学表达。使用卡方检验和 Fisher 确切检验分析 Gpx-2 免疫组织化学表达与临床参数之间的关联。使用 Kaplan-Meier 分析和对数秩检验验证 Gpx-2 表达强度与患者 5 年生存率之间的关系。共有 101 例（80.80%）样本具有强 Gpx-2 蛋白表达，24 例（19.20%）样本表达水平较低。Gpx-2 的高表达与肿瘤的组织学分级（<0.001）、PCNA 免疫组织化学表达（<0.001）、浸润深度（=0.001）和血管侵犯（<0.001）相关。我们可以得出结论，Gpx-2 的高表达与结肠癌患者生存时间缩短有关（对数秩检验，<0.001）。
