Stoyukhina A S, Musatkina I V
Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian Federation, 119021.
Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, 2/1 Barrikadnaya St., Moscow, Russian Federation, 123995.
Vestn Oftalmol. 2016;132(3):66-81. doi: 10.17116/oftalma2016132366-81.
Intraocular metastases account for 64-67% of all metastatic ocular tumors, of them 88-90.7% are found in the choroid. By the time the metastasis is diagnosed, 30-44% of patients usually have their primary lesion identified. In oncology patients with multiple and/or bilateral choroidal involvement, the diagnosis can be easily determined at ophthalmoscopy, while in those whose anamnesis is unburdened, this task is quite challenging. Aim - to define diagnostic criteria of choroidal metastases that would consider data provided by state-of-the-art instrumental assessment.
The study enrolled 5 patients (3 women and 2 men) with choroidal metastases of different origin. The mean patient age at the time of ocular involvement was 47.8 years (38-60 years). Oncological anamnesis was burdened in only 2 cases.
Due to the small number of cases and diverse clinical presentation, we considered appropriate to describe each case separately.
The absence of a known pre-existing lesion is typical of the younger age group. By analyzing optical coherence tomography data, we are able to list the most common signs of all choroidal metastases: hummocky profile of the choroid and a high neuroepithelium detachment accompanied by edema and photoreceptor damage. Fluorescein angiography diagnostic criteria are the following: spotted hyperfluorescence that begins in the arterial phase and gradually increases in intensity, while choroidal fluorescence is blocked during the whole examination; almost confluent hyperfluorescence with brighter pin-points along the margin of the lesion seen in the later phases. Evaluation of autofluorescence is auxiliary, but can provide an idea of the disease duration.
眼内转移瘤占所有转移性眼部肿瘤的64 - 67%,其中88 - 90.7%发生于脉络膜。在转移瘤被诊断时,30 - 44%的患者通常已确定其原发病灶。在患有多发性和/或双侧脉络膜受累的肿瘤患者中,通过检眼镜检查可轻松做出诊断,而在那些无相关既往史的患者中,这项任务颇具挑战性。目的——确定脉络膜转移瘤的诊断标准,该标准应考虑最新仪器评估所提供的数据。
本研究纳入了5例不同来源脉络膜转移瘤患者(3例女性,2例男性)。眼部受累时患者的平均年龄为47.8岁(38 - 60岁)。仅有2例患者有肿瘤病史。
由于病例数量少且临床表现多样,我们认为分别描述每个病例是合适的。
在较年轻的年龄组中,典型表现是不存在已知的既往病变。通过分析光学相干断层扫描数据,我们能够列出所有脉络膜转移瘤最常见的体征:脉络膜呈丘状外形以及高度的神经上皮脱离,并伴有水肿和光感受器损伤。荧光素血管造影的诊断标准如下:斑点状高荧光始于动脉期,强度逐渐增加,而在整个检查过程中脉络膜荧光被遮挡;在后期可见几乎融合的高荧光,病变边缘有更亮的点状荧光。自发荧光评估是辅助性的,但可提供有关疾病病程的信息。