Brovkina A F, Budzinskaya M V, Stoyukhina A S, Musatkina I V
Russian Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, 2/1 Barrikadnaya St., Moscow, Russian Federation, 125993.
Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021.
Vestn Oftalmol. 2016 Jul-Aug;132(4):10-19. doi: 10.17116/oftalma2016132410-19.
to determine potential benefits of optical coherence tomography (OCT) for precise diagnosis of choroidal hemangioma (CH).
A total of 27 patients (22 women, 5 men) with unilateral CH were examined. The age at diagnosis ranged from 30 to 76 years and averaged 53.7±5.29 years. Tumor thickness varied from 0.9 to 5.3 mm (2.17±0.41 mm; median of 1.9 mm), basal diameter - from 2.64 to 13.86 mm (median of 7.7 mm).
Having analyzed OCT findings in CH patients, we came to the conclusion that retinal architectonics does not get distorted (like in cystic dystrophy, for example) before the tumor prominence reaches 1.8 mm. As to retinal edema, it is associated with even greater tumor thicknesses. It should be also noted that any of the CH-related morphofunctional changes in the retina take a really long time to progress. At autofluorescence assessment, choroidal hemangioma had the appearance of a large hypoautofluorescent spot. Areas of fibrosis as well as hyperplasia or atrophy of the retinal pigment epithelium (RPE) also exhibited hypoautofluorescence. Sites of hyperautofluorescence corresponded to lipofuscin deposits. In two cases, there were wide zones of moderate hyperautofluorescence around the tumor due to recent subretinal effusion and photoreceptor damage. Hypoautofluorescent spots within these hyperautofluorescent areas corresponded to RPE atrophy by OCT.
Ophthalmoscopic presentation of choroidal hemangioma may be not comprehensive enough; therefore modern diagnostic methods, such as widely accepted fluorescence angiography and also spectral OCT (especially, in the «deeper penetration mode» for examination of the choroid) and autofluorescence assessment in the MultiColor mode may be used to ensure a more precise diagnosis.
确定光学相干断层扫描(OCT)对脉络膜血管瘤(CH)精确诊断的潜在益处。
共检查了27例单侧CH患者(22例女性,5例男性)。诊断时年龄在30至76岁之间,平均为53.7±5.29岁。肿瘤厚度在0.9至5.3毫米之间(2.17±0.41毫米;中位数为1.9毫米),基底直径在2.64至13.86毫米之间(中位数为7.7毫米)。
分析CH患者的OCT检查结果后,我们得出结论,在肿瘤突出达到1.8毫米之前,视网膜结构不会像在囊性营养不良等疾病中那样发生扭曲。至于视网膜水肿,则与更大的肿瘤厚度相关。还应注意的是,视网膜中任何与CH相关的形态功能变化进展都非常缓慢。在自发荧光评估中,脉络膜血管瘤表现为一个大的低自发荧光斑点。纤维化区域以及视网膜色素上皮(RPE)的增生或萎缩区域也表现为低自发荧光。高自发荧光部位对应脂褐素沉积。在两例病例中,由于近期视网膜下积液和光感受器损伤,肿瘤周围出现了宽的中度高自发荧光区域。这些高自发荧光区域内的低自发荧光斑点通过OCT对应RPE萎缩。
脉络膜血管瘤的检眼镜表现可能不够全面;因此,可使用现代诊断方法,如广泛应用的荧光血管造影以及光谱OCT(特别是在“深层穿透模式”下检查脉络膜)和多色模式下的自发荧光评估,以确保更精确的诊断。