[慢性丙型肝炎病毒感染：内科医生的观点（第2部分）]

[Chronic HCV infection: An internist's opinion (Part 2)].

作者信息

Zubkin M L, Chervinko V I, Ovchinnikov Yu V, Kryukov E V, Kotenko O N

机构信息

G.N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow, Russia; Branch, S.M. Kirov Military Medical Academy, Moscow, Russia.

Branch, S.M. Kirov Military Medical Academy, Moscow, Russia.

出版信息

Ter Arkh. 2016;88(11):138-148. doi: 10.17116/terarkh20168811138-148.

DOI:10.17116/terarkh20168811138-148

PMID:28635834

Abstract

Hepatitis C virus (HCV) infection results in not only chronic hepatitis and subsequent complications as liver cirrhosis and hepatocellular carcinoma, but also in a significant number of other diseases, the so-called extrahepatic manifestations of chronic HCV infection. In addition to lymphoproliferative and autoimmune disorders discussed in Part 1 of this review, many other diseases turned to be associated with chronic HCV infection. Part 2 of this review is dedicated to the analysis of the relationship of chronic HCV-infection to the development of some endocrine diseases, such as thyroiditis and diabetes mellitus, and cardiovascular disorders. It also provides the characteristics of the currently available antiviral agents and considers whether they may be used in patents with extrahepatic manifestations of chronic HCV infection.

摘要

丙型肝炎病毒（HCV）感染不仅会导致慢性肝炎以及随后的肝硬化和肝细胞癌等并发症，还会引发大量其他疾病，即所谓的慢性HCV感染的肝外表现。除了本综述第1部分中讨论的淋巴增殖性疾病和自身免疫性疾病外，许多其他疾病也被发现与慢性HCV感染有关。本综述的第2部分致力于分析慢性HCV感染与某些内分泌疾病（如甲状腺炎和糖尿病）以及心血管疾病的发生之间的关系。它还介绍了目前可用的抗病毒药物的特点，并探讨了它们是否可用于患有慢性HCV感染肝外表现的患者。