Astaf'eva L I, Kadashev B A, Shishkina L V, Kalinin P L, Kutin M A, Sidneva Yu G, Sharipov O I
Burdenko Neurosurgical Institute, Moscow, Russia.
Zh Vopr Neirokhir Im N N Burdenko. 2016;80(3):82-90. doi: 10.17116/neiro201680382-90.
An increased blood level of the thyroid stimulating hormone (TSH) is usually associated with primary hypothyroidism (PHT) but can also be observed in such rare cases as TSH-secreting pituitary tumor. The article describes four clinical cases of elevated TSH blood levels: 1) TSH-secreting pituitary adenoma with hyperthyroidism; 2) TSH-secreting adenoma with hypothyroidism; 3) hormonally inactive pituitary adenoma combined with primary hypothyroidism; 4) reversible thyrotropic hyperplasia. These clinical situations substantiate the importance of considering different diagnoses in a patient with a pituitary gland tumor associated with an increased TSH blood level.
促甲状腺激素（TSH）血液水平升高通常与原发性甲状腺功能减退症（PHT）相关，但在诸如分泌TSH的垂体瘤等罕见病例中也可观察到。本文描述了4例TSH血液水平升高的临床病例：1）伴有甲状腺功能亢进症的分泌TSH的垂体腺瘤；2）伴有甲状腺功能减退症的分泌TSH的腺瘤；3）无激素活性的垂体腺瘤合并原发性甲状腺功能减退症；4）可逆性促甲状腺激素细胞增生。这些临床情况证实了在TSH血液水平升高且伴有垂体瘤的患者中考虑不同诊断的重要性。
