Gabusi A, Morandi L, Asioli S, Foschini M P
Deparment of Biomedical and Neuromotor Sciences, section of Anatomic Pathology at Bellaria Hospital, Bologna, Italy.
Pathologica. 2017 Mar;109(1):60-65.
Notwithstanding extended surgical approaches or adjuvant chemoradiotherapy, the development of multiple neoplastic lesions arising in the oral cavity after treatment still represents a critical clinical challenge in the management of patients with oral squamous cell carcinoma. Such clinical behavior of oral squamous cell carcinoma is nowadays better known as "field" cancerization effect as suggested by Slaughter, the author that for the first time tried to describe it in a scientific paper. Field cancerization is now widely accepted not only in head and neck oncology but also in other anatomical districts as well as in different types of epithelial neoplasia. A brief history of the theory of field cancerization is here proposed and future perspectives deriving from new molecular techniques are discussed.
尽管采用了扩大手术方法或辅助放化疗，但口腔鳞状细胞癌患者治疗后口腔内出现多个肿瘤性病变的情况，在临床管理中仍是一项严峻挑战。如今，口腔鳞状细胞癌的这种临床行为被称为“场”癌变效应，正如首次尝试在科学论文中描述它的作者斯劳特所指出的那样。场癌变如今不仅在头颈肿瘤学领域，而且在其他解剖区域以及不同类型的上皮性肿瘤中都已被广泛接受。本文简要介绍了场癌变理论的历史，并讨论了源自新分子技术的未来前景。
