Iowa Institute for Oral Health Research, University of Iowa College of Dentistry, 801 Newton Road, Iowa City, Iowa.
Department of Prosthodontics, University of Iowa College of Dentistry, Iowa City, Iowa.
J Biomed Mater Res B Appl Biomater. 2018 May;106(4):1421-1430. doi: 10.1002/jbm.b.33945. Epub 2017 Jun 21.
The purpose of this work was to investigate the effect of strontium partial replacement for calcium on the crystallization behavior, microstructure and solubility of fluorapatite glass-ceramics. Four glass compositions were prepared with increasing amounts of strontium partially replacing calcium. The crystallization behavior was analyzed by differential scanning calorimetry and X-ray diffraction (XRD). The microstructure was investigated by scanning electron microscopy. The chemical solubility was quantified according to ISO standard 10993-14. The amount of strontium released in solution after incubation in TRIS-HCl or citric acid buffer was measured by atomic absorption spectroscopy. XRD analyses revealed that partially substituted strontium-fluorapatite and strontium-åkermanite crystallized after strontium additions. The lattice cell volume of both phases increased linearly with the amount of strontium in the composition. Strontium additions led to a reduction in crystal size and an increase in crystal number density. The chemical solubility and amount of strontium released in solution increased linearly with the amount of strontium present in the composition in both TRIS-HCl and citric acid buffers. Total amounts of strontium released reached a maximum of 547 ± 80 ppm in TRIS-HCl and 1252 ± 290 ppm in citric acid buffer for the glass composition with the highest amount of strontium. For all strontium-containing compositions, the amount released in TRIS-HCl continued to increase between 70 and 120 h, indicating sustained release rather than burst release. © 2017 Wiley Periodicals, Inc. J Biomater Res Part B: 106B: 1421-1430, 2018.
本工作旨在研究锶部分取代钙对氟磷灰石微晶玻璃的结晶行为、微观结构和溶解度的影响。用逐步增加锶取代量的方法制备了 4 种玻璃组成。用差示扫描量热法和 X 射线衍射（XRD）分析了结晶行为。用扫描电子显微镜研究了微观结构。根据 ISO 标准 10993-14 定量测定化学溶解度。通过原子吸收光谱法测量在 TRIS-HCl 或柠檬酸缓冲液中孵育后溶液中释放的锶量。XRD 分析表明，在锶添加后部分取代的锶-氟磷灰石和锶-钙长石相结晶。两相的晶格细胞体积随组成中锶量呈线性增加。锶添加导致晶体尺寸减小和晶体数密度增加。在 TRIS-HCl 和柠檬酸缓冲液中，化学溶解度和溶液中释放的锶量随组成中锶量的增加呈线性增加。在 TRIS-HCl 中释放的锶总量达到最高值 547 ± 80 ppm，在柠檬酸缓冲液中释放的锶总量达到最高值 1252 ± 290 ppm，对于含锶量最高的玻璃组成。对于所有含锶的组成物，在 70 和 120 h 之间，释放量继续增加，表明持续释放而不是爆发式释放。 © 2017 Wiley Periodicals, Inc. J 生物材料研究部分 B：106B：1421-1430，2018。
