Graduate School of Pharmaceutical Sciences, Kumamoto University , 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Priority Organization for Innovation and Excellence, Kumamoto University , 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Org Lett. 2017 Jul 7;19(13):3672-3675. doi: 10.1021/acs.orglett.7b01719. Epub 2017 Jun 21.
An efficient method for accessing enantiomerically pure stereopentads via a catalytic asymmetric sequential aldol reaction has been developed for the first time. The enantioselective sequential aldol reaction produces a wide range of chiral stereopentad precursors in good yields with excellent enantioselectivities. The key to success is the use of the sequential catalytic system involving a chiral phosphine oxide catalyst and trichlorosilyl triflate.
首次开发了一种通过催化不对称顺序羟醛反应来获得对映体纯立体五聚体的有效方法。对映选择性顺序羟醛反应以优异的对映选择性和良好的收率生成广泛的手性立体五聚体前体。成功的关键是使用涉及手性氧化膦催化剂和三氯硅基三氟甲磺酸酯的顺序催化体系。
