同源单纯疱疹病毒1型（HSV1）和α-突触核蛋白肽可刺激帕金森病患者的T细胞反应。
Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease.
作者信息
Caggiu E, Paulus K, Galleri G, Arru G, Manetti R, Sechi G P, Sechi L A
机构信息
Dipartimento di Scienze Biomediche, Sezione di Microbiologia, Università di Sassari, Italy.
Dipartimento di Medicina Clinica e Sperimentale, Università di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy.
出版信息
J Neuroimmunol. 2017 Sep 15;310:26-31. doi: 10.1016/j.jneuroim.2017.06.004. Epub 2017 Jun 15.
Environmental factors are implicated in the development of Parkinson's disease (PD). The aim of this study is to investigate the role of cell-mediated immunity upon a specific immune-stimulation with HSV-1 and human alpha-synuclein homologues peptides by using the intracellular cytokine method on Parkinson's patients and healthy controls. The study showed, for the first time, a specific response to TNF-α CD8, CD4 and NK cells after stimulation in PD patients. Our data show a possible role of the immune system in the pathogenesis of Parkinson's disease, and that HSV-1 infections may lead to a progression of the disease.
环境因素与帕金森病（PD）的发病有关。本研究旨在通过细胞内细胞因子法，对帕金森病患者和健康对照者进行单纯疱疹病毒1型（HSV-1）和人α-突触核蛋白同源肽特异性免疫刺激后，研究细胞介导免疫的作用。该研究首次显示，帕金森病患者在刺激后，TNF-α、CD8、CD4和NK细胞出现特异性反应。我们的数据表明免疫系统在帕金森病发病机制中可能发挥作用，且HSV-1感染可能导致疾病进展。
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