Grant Nazaneen, Wong Richard J, Kraus Dennis H, Schoder Heiko, Branski Ryan C
Department of Otolaryngology, New York University School of Medicine, New York, NY, USA.
Ear Nose Throat J. 2017 Jun;96(6):218-224. doi: 10.1177/014556131709600621.
The potential for the misinterpretation of positron-emission tomography (PET) scans in the context of a possible malignancy has been confirmed in a case report showing increased 18F-fluorodeoxyglucose (FDG) uptake after unilateral vocal fold augmentation medialization. We sought to expand these findings by investigating FDG uptake in a larger cohort of patients via a retrospective chart review. We examined the records of 15 adults-8 men and 7 women-who had undergone vocal fold augmentation for unilateral vocal fold paralysis and at least one subsequent PET scan. The differences in PET standard uptake value (SUV) between the injected and noninjected vocal folds were assessed via the Wilcoxon signed-rank test. A Spearman rank correlation coefficient was then used to estimate the relationship between differences in PET uptake and the length of time between the injection and the follow-up PET scan. The mean SUV of the injected vocal folds was 3.70, and the mean in the noninjected folds was 2.97. The difference did not achieve statistical significance (p = 0.34). In addition, the rank correlation coefficient with regard to the association between the difference in PET uptake and the duration between injection and PET was -0.24, suggesting an inverse relationship. However, the correlation coefficient did not differ significantly from zero (p = 0.34). We conclude that PET uptake after vocal fold augmentation medialization is variable and that it can increase substantially. This information should be considered in the context of the diagnostic accuracy of malignancy on PET.
在一份病例报告中证实，在可能存在恶性肿瘤的情况下，正电子发射断层扫描（PET）扫描可能会被误读。该病例报告显示，单侧声带强化内移术后18F-氟脱氧葡萄糖（FDG）摄取增加。我们试图通过回顾性病历审查，在更大的患者队列中研究FDG摄取情况，以扩展这些发现。我们检查了15名成年人（8名男性和7名女性）的记录，这些患者因单侧声带麻痹接受了声带强化手术，并至少进行了一次后续PET扫描。通过Wilcoxon符号秩检验评估注射侧和未注射侧声带的PET标准摄取值（SUV）差异。然后使用Spearman等级相关系数来估计PET摄取差异与注射与后续PET扫描之间的时间间隔之间的关系。注射侧声带的平均SUV为3.70，未注射侧声带的平均SUV为2.97。差异未达到统计学意义（p = 0.34）。此外，PET摄取差异与注射和PET之间持续时间的关联的等级相关系数为-0.24，表明存在负相关关系。然而，相关系数与零无显著差异（p = 0.34）。我们得出结论，声带强化内移术后的PET摄取是可变的，并且可能会大幅增加。在PET对恶性肿瘤的诊断准确性的背景下，应考虑这些信息。
