Huang Wei, Chao Nelson J
Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, Durham, NC, USA.
Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, Durham, NC, USA.
Hematol Oncol Stem Cell Ther. 2017 Dec;10(4):211-219. doi: 10.1016/j.hemonc.2017.05.006. Epub 2017 Jun 13.
Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (AHSCT) and the major cause of nonrelapse morbidity and mortality of AHSCT. In AHSCT, donor T cells facilitate hematopoietic stem cell (HSC) engraftment, contribute to anti-infection immunity, and mediate graft-versus-leukemia (GVL) responses. However, activated alloreactive T cells also attack recipient cells in vital organs, leading to GVHD. Different T-cell subsets, including naïve T (T) cells, memory T (T) cells, and regulatory T (T) cells mediate different forms of GVHD and GVL; T cells mediate severe GVHD, whereas T cells do not cause GVHD, but preserve T-cell function including GVL. In addition, metabolic reprogramming controls T-cell differentiation and activation in these disease states. This minireview focuses on the role and the related mechanisms of T cells in AHSCT, and the potential manipulation of T cells in AHSCT.
移植物抗宿主病（GVHD）是异基因造血干细胞移植（AHSCT）的主要并发症，也是AHSCT非复发发病率和死亡率的主要原因。在AHSCT中，供体T细胞促进造血干细胞（HSC）植入，有助于抗感染免疫，并介导移植物抗白血病（GVL）反应。然而，活化的同种异体反应性T细胞也会攻击重要器官中的受体细胞，导致GVHD。不同的T细胞亚群，包括初始T（T）细胞、记忆T（T）细胞和调节性T（T）细胞介导不同形式的GVHD和GVL；T细胞介导严重的GVHD，而T细胞不会引起GVHD，但保留包括GVL在内的T细胞功能。此外，代谢重编程在这些疾病状态下控制T细胞分化和活化。本综述聚焦于T细胞在AHSCT中的作用及相关机制，以及AHSCT中对T细胞的潜在调控。
