"Riddle Me This": Substrate Channeling Solves the Paradigms of cAMP-Dependent Activation of PKA.
作者信息
Ramírez-Sarmiento César A
机构信息
Institute for Biological and Medical Engineering, Schools of Engineering, Medicine, and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.
出版信息
Biophys J. 2017 Jun 20;112(12):2451-2453. doi: 10.1016/j.bpj.2017.05.021.
Abstract
摘要
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Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling.cAMP与磷酸二酯酶的平行变构作用协调cAMP信号转导中的激活和终止阶段。
Biophys J. 2015 Sep 15;109(6):1251-63. doi: 10.1016/j.bpj.2015.06.067. Epub 2015 Aug 11.
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Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.磷酸二酯酶（PDE）与蛋白激酶A（PKA）复合物中的活性位点偶联促进哺乳动物环磷酸腺苷（cAMP）信号转导的重置。
Biophys J. 2014 Sep 16;107(6):1426-40. doi: 10.1016/j.bpj.2014.07.050.
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Mechanisms of protein kinase A anchoring.蛋白激酶 A 的锚定机制。
Int Rev Cell Mol Biol. 2010;283:235-330. doi: 10.1016/S1937-6448(10)83005-9.
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Localized effects of cAMP mediated by distinct routes of protein kinase A.由蛋白激酶A的不同途径介导的cAMP的局部效应。
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