少数有益共生体：肠道微生物利用 IFN-γ 抵抗沙门氏菌。
A Few Good Commensals: Gut Microbes Use IFN-γ to Fight Salmonella.
机构信息
Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA.
Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA.
出版信息
Immunity. 2017 Jun 20;46(6):977-979. doi: 10.1016/j.immuni.2017.06.010.
Whereas strong evidence supports the notion that the microbiota promotes immune system maturation in multiple tissues, the identity of the specific microbes that elicit protective immunity to different infections is less clear. In a recent issue of Cell Host & Microbe, Thiemann et al. (2017) report the identification of specific gut bacteria that protect from Salmonella infection by priming host IFN-γ responses.
尽管有强有力的证据表明，微生物群有助于多种组织中的免疫系统成熟，但具体的微生物是什么，以及它们如何引发针对不同感染的保护性免疫，还不太清楚。在最近一期的《Cell Host & Microbe》杂志上，Thiemann 等人（2017）报告了特定肠道细菌通过激活宿主 IFN-γ 反应来预防沙门氏菌感染的鉴定。
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