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调节毛囊干细胞的 T 细胞。

T-Regulating Hair Follicle Stem Cells.

机构信息

Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.

Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.

出版信息

Immunity. 2017 Jun 20;46(6):979-981. doi: 10.1016/j.immuni.2017.06.011.

DOI:10.1016/j.immuni.2017.06.011
PMID:28636968
Abstract

Regulatory T (Treg) cells are well known to modulate inflammatory responses. In a recent issue of Cell, Ali et al. (2017) reveal a function for Treg cells in stem cell maintenance by showing that skin-resident Foxp3 Treg cells preferentially localize to the hair follicle stem cell (HFSC) niche to control HFSC-mediated hair regeneration.

摘要

调节性 T（Treg）细胞已被证实可调节炎症反应。在最近一期的《Cell》杂志上，Ali 等人（2017）揭示了 Treg 细胞在干细胞维持中的一个功能，即皮肤驻留的 Foxp3 Treg 细胞优先定位于毛囊干细胞（HFSC）龛位，以控制 HFSC 介导的毛发再生。

相似文献

1
T-Regulating Hair Follicle Stem Cells.调节毛囊干细胞的 T 细胞。
Immunity. 2017 Jun 20;46(6):979-981. doi: 10.1016/j.immuni.2017.06.011.
2
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.皮肤中的调节性T细胞促进上皮干细胞分化。
Cell. 2017 Jun 1;169(6):1119-1129.e11. doi: 10.1016/j.cell.2017.05.002. Epub 2017 May 25.
3
Regulatory T cells in skin.皮肤中的调节性T细胞。
Immunology. 2017 Nov;152(3):372-381. doi: 10.1111/imm.12791. Epub 2017 Aug 4.
4
Notch Signaling Promotes Development of Allergic Rhinitis by Suppressing Foxp3 Expression and Treg Cell Differentiation.Notch信号通路通过抑制Foxp3表达和调节性T细胞分化促进变应性鼻炎的发展。
Int Arch Allergy Immunol. 2019;178(1):33-44. doi: 10.1159/000493328. Epub 2018 Nov 2.
5
FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.FOXC1维持毛囊干细胞微环境并调控干细胞静止状态，以保留长期的组织再生潜能。
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1506-15. doi: 10.1073/pnas.1601569113. Epub 2016 Feb 24.
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Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells.小鼠间充质基质细胞扩增CD4+ CD25+ FoxP3+调节性T细胞和耐受性树突状细胞需要Jagged-1。
Stem Cell Res Ther. 2015 Mar 11;6(1):19. doi: 10.1186/s13287-015-0021-5.
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Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche.糖皮质激素信号和调节性 T 细胞共同维持毛囊干细胞龛。
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Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells.促进鸡皮疙瘩形成的细胞类型构成了一个调节毛囊干细胞的龛。
Cell. 2020 Aug 6;182(3):578-593.e19. doi: 10.1016/j.cell.2020.06.031. Epub 2020 Jul 16.
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Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair.调节性 T 细胞控制 CXCL5-IL-17 炎症轴促进皮肤屏障修复过程中的毛囊干细胞分化。
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Jagged-1+ skin Tregs modulate cutaneous wound healing.Jagged-1+ 皮肤调节性 T 细胞调节皮肤伤口愈合。
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引用本文的文献

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Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration.皮肤T细胞免疫与关键调节信号通路：对免疫介导性脱发和毛发再生的影响。
Genes Dis. 2025 Jan 8;12(5):101518. doi: 10.1016/j.gendis.2025.101518. eCollection 2025 Sep.
2
Cell Therapy for Androgenetic Alopecia: Elixir or Trick?细胞治疗雄激素性脱发：灵丹妙药还是骗局？
Stem Cell Rev Rep. 2023 Aug;19(6):1785-1799. doi: 10.1007/s12015-023-10532-2. Epub 2023 Jun 5.
3
The potential of regulatory T cell-based therapies for alopecia areata.
基于调节性 T 细胞的疗法治疗斑秃的潜力。
Front Immunol. 2023 May 2;14:1111547. doi: 10.3389/fimmu.2023.1111547. eCollection 2023.
4
A systematic summary of survival and death signalling during the life of hair follicle stem cells.系统总结毛囊干细胞存活和死亡信号转导的生命过程。
Stem Cell Res Ther. 2021 Aug 11;12(1):453. doi: 10.1186/s13287-021-02527-y.
5
Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations.皮肤淋巴腺瘤是一种独特的具有毛母质细胞样特征的淋巴上皮肿瘤，具有弥漫性雄激素受体免疫反应性、Reed-Sternberg 样细胞中的 Notch1 配体以及常见的 EGFR 体细胞突变。
Am J Surg Pathol. 2021 Oct 1;45(10):1382-1390. doi: 10.1097/PAS.0000000000001727.
6
Tissue Treg Secretomes and Transcription Factors Shared With Stem Cells Contribute to a Treg Niche to Maintain Treg-Ness With 80% Innate Immune Pathways, and Functions of Immunosuppression and Tissue Repair.组织 Treg 分泌组和与干细胞共享的转录因子有助于形成 Treg 生态位，维持 Treg 特性，其中 80%为固有免疫途径，并具有免疫抑制和组织修复功能。
Front Immunol. 2021 Feb 5;11:632239. doi: 10.3389/fimmu.2020.632239. eCollection 2020.
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FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity.FOXP3+ Treg 作为促进抗肿瘤免疫的治疗靶点。
Expert Opin Ther Targets. 2018 Apr;22(4):353-363. doi: 10.1080/14728222.2018.1451514. Epub 2018 Apr 10.