Ali Niwa, Rosenblum Michael D
Department of Dermatology, University of California at San Francisco, San Francisco, CA, USA.
Cutaneous Medicine Unit, St John's Institute of Dermatology, King's College London, London, UK.
Immunology. 2017 Nov;152(3):372-381. doi: 10.1111/imm.12791. Epub 2017 Aug 4.
Foxp3 CD4 regulatory T (Treg) cells are a subset of immune cells that function to regulate tissue inflammation. Skin is one of the largest organs and is home to a large proportion of the body's Treg cells. However, relative to other tissues (such as the spleen and gastrointestinal tract) the function of Treg cells in skin is less well defined. Here, we review our understanding of how Treg cells migrate to skin and the cellular and molecular pathways required for their maintenance in this tissue. In addition, we outline what is known about the specialized functions of Treg cells in skin. Namely, the orchestration of stem cell-mediated hair follicle regeneration, augmentation of wound healing, and promoting adaptive immune tolerance to skin commensal microbes. A comprehensive understanding of the biology of skin Treg cells may lead to novel therapeutic approaches that preferentially target these cells to treat cutaneous autoimmunity, skin cancers and disorders of skin regeneration.
叉头框蛋白3（Foxp3）阳性CD4调节性T（Treg）细胞是一类免疫细胞亚群，其功能是调节组织炎症。皮肤是最大的器官之一，是体内大部分Treg细胞的栖居地。然而，相对于其他组织（如脾脏和胃肠道），Treg细胞在皮肤中的功能尚不太明确。在此，我们综述了对Treg细胞如何迁移至皮肤以及在该组织中维持其功能所需的细胞和分子途径的理解。此外，我们概述了已知的Treg细胞在皮肤中的特殊功能。即，协调干细胞介导的毛囊再生、促进伤口愈合以及促进对皮肤共生微生物的适应性免疫耐受。全面了解皮肤Treg细胞的生物学特性可能会带来新的治疗方法，这些方法可优先靶向这些细胞来治疗皮肤自身免疫性疾病、皮肤癌和皮肤再生障碍。
