Vyska K, Mehdorn H M, Machulla H J, Knust E J
Neurol Res. 1985 Jun;7(2):63-7. doi: 10.1080/01616412.1985.11739702.
A new model is described applying dynamic positron emission tomography (dPET) and 3-fluoro-deoxyglucose (3FDG) to the measurement of local cerebral perfusion and glucose transport across the blood-brain-barrier (BBB). The model takes advantage of 3FDG being practically not metabolized in brain and being transported back from tissue into the circulation. Simultaneous registration of tracer concentration in blood and tissue by dPET permits the in vivo determination of the Michaelis-Menten constant (K) and maximal velocity (V) for 3FDG and glucose transport across the BBB as well as the determination of local perfusion rate. Values obtained in normal cortex using this method were K = 6.3 mumol/g and V = 2.46 mumol/g min. Local perfusion rate ranged between 0.8 and 0.98 ml/min g.
描述了一种新模型，该模型应用动态正电子发射断层扫描（dPET）和3-氟脱氧葡萄糖（3FDG）来测量局部脑灌注以及葡萄糖跨血脑屏障（BBB）的转运。该模型利用了3FDG在脑中几乎不被代谢且从组织转运回循环系统这一特性。通过dPET同时记录血液和组织中的示踪剂浓度，可以在体内确定3FDG和葡萄糖跨血脑屏障转运的米氏常数（K）和最大速度（V），以及确定局部灌注率。使用该方法在正常皮质中获得的值为K = 6.3 μmol/g和V = 2.46 μmol/g·min。局部灌注率在0.8至0.98 ml/min·g之间。
