Mehdorn H M, Vyska K, Machulla H J, Knust E J
Neurol Res. 1985 Jun;7(2):68-74. doi: 10.1080/01616412.1985.11739703.
Dynamic positron emission tomography (dPET) and 3-fluoro-deoxy-glucose (3FDG) have been applied to the followup of selected patients undergoing extracranial-intracranial (EC-IC) bypass surgery. To determine glucose transport across the blood-brain-barrier and local perfusion rate a new mathematical model has been used. Immediately following EC-IC surgery, dPET shows an increase in perfusion of approx. 7 ml/min 100g over both the operated and the contralateral hemispheres indicative of reversal of interhemispheric steal. Followup studies show reduction of local perfusion rate combined with an improvement of glucose transport rates. This finding suggests improvement of cerebral metabolic capacity following improvement of perfusion suggestive of longterm beneficial effects of EC-IC bypass.
动态正电子发射断层扫描（dPET）和3-氟脱氧葡萄糖（3FDG）已应用于接受颅外-颅内（EC-IC）搭桥手术的部分患者的随访。为了确定葡萄糖跨血脑屏障的转运和局部灌注率，使用了一种新的数学模型。EC-IC手术后立即进行的dPET显示，手术侧和对侧半球的灌注均增加了约7 ml/min 100g，这表明半球间盗血现象得到了逆转。随访研究显示局部灌注率降低，同时葡萄糖转运率提高。这一发现表明灌注改善后脑代谢能力得到改善，提示EC-IC搭桥手术具有长期有益效果。
