Sanadze A G, Sidnev D V, Tumurov D A
Pirogov Russian National Medical Research University, Moscow, Russia; Moscow City Health Department, Moscow Myasthenia Center, SFHI Municipal Clinical Hospital #51, Moscow, Russia; Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russia.
Pirogov Russian National Medical Research University, Moscow, Russia; Moscow City Health Department, Moscow Myasthenia Center, SFHI Municipal Clinical Hospital #51, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(5):77-80. doi: 10.17116/jnevro20171175177-80.
The authors studied two patients with Lambert-Eaton myasthenic syndrome (LEMS) in whom the repeated examination did not find specific of LEMS P/Q type voltage-gates calcium channel autoantibodies. The results of clinical testing and electrophysiological examination showed the typical character of movement disorders with the absence of tendon reflexes and signs of disautonomia as well as a decrease in M-response amplitude and phenomena of decrement with low frequency- and increment with high frequency stimulation. Both patients revealed no signs of paraneoplastic process. Autoimmune character of the damage was confirmed by the effectiveness of treatment with glucocorticoid hormones.
作者研究了两名兰伯特-伊顿肌无力综合征（LEMS）患者，其反复检查未发现LEMS P/Q型电压门控钙通道自身抗体。临床检测和电生理检查结果显示出典型的运动障碍特征，包括腱反射消失、自主神经功能障碍体征、M反应幅度降低以及低频刺激递减和高频刺激递增现象。两名患者均未显示副肿瘤综合征迹象。糖皮质激素治疗的有效性证实了损伤的自身免疫性质。
