新型H1受体拮抗剂特非那定的药理学与临床疗效
Pharmacology and clinical efficacy of terfenadine, a new H1-receptor antagonist.
作者信息
Connell J T
出版信息
Pharmacotherapy. 1985 Jul-Aug;5(4):201-8. doi: 10.1002/j.1875-9114.1985.tb03418.x.
Abstract
Terfenadine is the first of a new class of non-sedating H1 antihistamines. It differs from chlorpheniramine in its lower anticholinergic activity in rabbit salivation tests. In animal model distribution studies, the drug is not found in the brain. In most clinical studies sedation attributed to terfenadine was on the order of that observed with placebo. Clinical trials of efficacy show that at best terfenadine is slightly less effective than or as effective as chlorpheniramine.
摘要
特非那定是新型非镇静性H1抗组胺药中的首个药物。在兔唾液分泌试验中，它与氯苯那敏相比，具有较低的抗胆碱能活性。在动物模型分布研究中，未在脑中发现该药物。在大多数临床研究中，特非那定所致的镇静作用与安慰剂相当。疗效临床试验表明，特非那定充其量比氯苯那敏略差或与之疗效相当。
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