Liu Xiaohua, Jiang Kaida
Division of Mood Disorders, Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
Shanghai Arch Psychiatry. 2016 Dec 25;28(6):343-345. doi: 10.11919/j.issn.1002-0829.216073.
Depression is highly prevalent and one of the major contributors to disability worldwide. However, one of the findings from the DSM-5 field trials was that inter-rater reliability for diagnosing major depressive disorder was very poor. Why is diagnosing MDD so challenging? This article attempts to explain why undefined pathogenesis and complicated phenotypes complicate the diagnosis of MDD. However, further biomarker and translational research is still necessary to help clinicians screen and diagnose depression in the future rather than relying solely on current subjective diagnostic criteria.
抑郁症极为普遍，是全球致残的主要原因之一。然而，《精神疾病诊断与统计手册》第五版（DSM - 5）现场试验的结果之一是，诊断重度抑郁症的评定者间信度非常低。为什么诊断重度抑郁症如此具有挑战性？本文试图解释未明确的发病机制和复杂的表型如何使重度抑郁症的诊断变得复杂。然而，未来仍需要进一步的生物标志物和转化研究，以帮助临床医生筛查和诊断抑郁症，而不是仅仅依赖当前主观的诊断标准。
