Jeon Tae Joo, Park Ji Young
Tae Joo Jeon, Ji Young Park, Division of Gastroenterology, Department of Internal Medicine, Inje University College of Medicine, Sanggye Paik Hospital, Seoul 01757, South Korea.
World J Gastroenterol. 2017 Jun 7;23(21):3883-3889. doi: 10.3748/wjg.v23.i21.3883.
To investigated the prognostic value of the neutrophil-lymphocyte ratio (NLR) in patients with acute pancreatitis and determined an optimal cut-off value for the prediction of adverse outcomes in these patients.
We retrospectively analyzed 490 patients with acute pancreatitis diagnosed between March 2007 and December 2012. NLRs were calculated at admission and 24, 48, and 72 h after admission. Patients were grouped according to acute pancreatitis severity and organ failure occurrence, and a comparative analysis was performed to compare the NLR between groups.
Among the 490 patients, 70 had severe acute pancreatitis with 31 experiencing organ failure. The severe acute pancreatitis group had a significantly higher NLR than the mild acute pancreatitis group on all 4 d (median, 6.14, 6.71, 5.70, and 4.00 4.74, 4.47, 3.20, and 3.30, respectively, < 0.05). The organ failure group had a significantly higher NLR than the group without organ failure on all 4 d (median, 7.09, 6.72, 6.27, and 6.24 4.85, 4.49, 3.35, and 2.34, respectively, < 0.05). The optimal cut-off value for baseline NLR was 4.76 in predicting severity and 4.88 in predicting organ failure in acute pancreatitis.
Elevated baseline NLR correlates with severe acute pancreatitis and organ failure.
探讨中性粒细胞与淋巴细胞比值（NLR）对急性胰腺炎患者的预后价值，并确定预测这些患者不良结局的最佳临界值。
我们回顾性分析了2007年3月至2012年12月期间诊断为急性胰腺炎的490例患者。在入院时以及入院后24、48和72小时计算NLR。根据急性胰腺炎的严重程度和器官衰竭的发生情况对患者进行分组，并进行比较分析以比较各组之间的NLR。
在490例患者中，70例患有重症急性胰腺炎，其中31例出现器官衰竭。重症急性胰腺炎组在所有4天的NLR均显著高于轻症急性胰腺炎组（中位数分别为6.14、6.71、5.70和4.00对4.74、4.47、3.20和3.30，P<0.05）。器官衰竭组在所有4天的NLR均显著高于无器官衰竭组（中位数分别为7.09、6.72、6.27和6.24对4.85、4.49、3.35和2.34，P<0.05）。急性胰腺炎中，预测严重程度的基线NLR最佳临界值为4.76，预测器官衰竭的最佳临界值为4.88。
基线NLR升高与重症急性胰腺炎和器官衰竭相关。
