Institute of Genetics and Biophysics -I.G.B., A. Buzzati-Traverso-, CNR, Via Pietro Castellino, 111, I-80131 Naples, Italy.
Theranostics. 2017 May 26;7(7):2108-2110. doi: 10.7150/thno.20460. eCollection 2017.
Cancer is a very complex disease, where cell alterations (i.e. gene mutations, dysregulated signaling pathway(s) and epigenetic modifications) contribute to its development and progression. Elucidating the connections among these cell modifications is a critical challenge, in order to understand the mechanisms which are activated from cancer cells to survive and proliferate. Interesting, Prof. Peng Hou and colleagues, at the First Affiliated Hospital of Xi'an Jiaotong University in China, identified unknown epigenetic mechanisms and their involvement in the tumorigenesis of B-RAF(V600E)-driven cancer.
癌症是一种非常复杂的疾病，细胞的改变（即基因突变、信号通路失调和表观遗传修饰）促成了癌症的发生和发展。阐明这些细胞改变之间的联系是一个关键的挑战，以便了解从癌细胞激活的机制，以存活和增殖。有趣的是，中国西安交通大学第一附属医院的侯鹏教授及其同事，确定了未知的表观遗传机制及其在 B-RAF(V600E)驱动的癌症发生中的作用。
