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使用便携式杂散场核磁共振扫描仪监测甲状旁腺激素（1-34）治疗去卵巢大鼠后骨髓中的细胞变化。

Monitoring of Cellular Changes in the Bone Marrow following PTH(1-34) Treatment of OVX Rats Using a Portable Stray-Field NMR Scanner.

作者信息

Hillel Inbar, Binderman Itzhak, Sarda Yifat, Nevo Uri

机构信息

Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel.

Department of Oral Biology, School of Dental Medicine, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv, Israel.

出版信息

J Osteoporos. 2017;2017:7910432. doi: 10.1155/2017/7910432. Epub 2017 May 30.

DOI:10.1155/2017/7910432
PMID:28638673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5468560/
Abstract

Osteoporosis is characterized by reduction in trabecular bone in conjunction with increased marrow cell adiposity. While these changes occur within weeks, monitoring of treatment efficacy as performed by DEXA is sensitive only to long-term changes. MRI is sensitive to bone marrow changes but is less affordable. In a recent study, we have shown that a stray-field NMR can monitor bone marrow cellular changes that are related to osteoporosis. To demonstrate sensitivity of a low-field tabletop NMR scanner to bone marrow dynamics following hormonal treatment in rats. Two-month-old female rats ( = 36) were ovariectomized (OVX) and dosed for the ensuing 3 or 5 weeks with 20 mg/kg of PTH(1-34). Hind limbs femurs and tibiae were isolated and underwent ex vivo microradiography and histology and NMR relaxometry at 6 weeks (preventive experiment) and 11 weeks (therapeutic treatment experiment) after OVX. OVX rats developed osteoporotic changes including adipogenic marrow compared to Sham and PTH treated rats. and ADC NMR relaxation coefficients were found to correlate with marrow composition. . This study suggests that stray-field NMR, an affordable method that is sensitive to the rapid cellular changes in bone marrow, may have a clinical value in monitoring hormonal treatment for osteoporosis.

摘要

骨质疏松症的特征是小梁骨减少，同时骨髓细胞脂肪增多。虽然这些变化在数周内就会发生，但像双能X线吸收法（DEXA）所进行的治疗效果监测仅对长期变化敏感。磁共振成像（MRI）对骨髓变化敏感，但费用较高。在最近的一项研究中，我们表明杂散场核磁共振（NMR）可以监测与骨质疏松症相关的骨髓细胞变化。为了证明低场台式NMR扫描仪对大鼠激素治疗后骨髓动态变化的敏感性。将36只2月龄雌性大鼠进行卵巢切除（OVX），并在随后的3或5周内给予20mg/kg的甲状旁腺激素（PTH）（1-34）。在卵巢切除术后6周（预防性实验）和11周（治疗性实验），分离后肢股骨和胫骨，进行离体显微放射摄影、组织学检查和NMR弛豫测量。与假手术组和PTH治疗组大鼠相比，OVX大鼠出现了骨质疏松性变化，包括骨髓脂肪生成。并且发现表观扩散系数（ADC）NMR弛豫系数与骨髓组成相关。这项研究表明，杂散场NMR是一种经济实惠的方法，对骨髓中快速的细胞变化敏感，可能在监测骨质疏松症的激素治疗方面具有临床价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b18/5468560/43be08b04520/JOS2017-7910432.010.jpg
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2
Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoblasts and Adipocytes and its Role in Treatment of Osteoporosis.骨髓间充质干细胞向成骨细胞和脂肪细胞的分化及其在骨质疏松症治疗中的作用。
Med Sci Monit. 2016 Jan 21;22:226-33. doi: 10.12659/msm.897044.
3
Influences of teriparatide administration on marrow fat content in postmenopausal osteopenic women using MR spectroscopy.
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Climacteric. 2016 Jun;19(3):285-91. doi: 10.3109/13697137.2015.1126576. Epub 2016 Jan 8.
4
In vivo assessment of aged human skin with a unilateral NMR scanner.使用单侧核磁共振扫描仪对老年人体皮肤进行体内评估。
NMR Biomed. 2015 Jun;28(6):656-66. doi: 10.1002/nbm.3304. Epub 2015 Apr 21.
5
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6
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7
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