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尼古丁可预防 REM 睡眠剥夺大鼠的学习和记忆损伤，其作用可被海马中的 DREAM 蛋白调节。

Nicotine-prevented learning and memory impairment in REM sleep-deprived rat is modulated by DREAM protein in the hippocampus.

机构信息

BRAINetwork Centre for Neurocognitive Sciences School of Health Sciences University Sains Malaysia Kubang Kerian Kelantan Malaysia.

School of Health Sciences University Sains Malaysia Kubang Kerian Kelantan Malaysia.

出版信息

Brain Behav. 2017 Apr 20;7(6):e00704. doi: 10.1002/brb3.704. eCollection 2017 Jun.

DOI:10.1002/brb3.704
PMID:28638710
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5474708/
Abstract

INTRODUCTION

REM sleep deprivation is associated with impairment in learning and memory, and nicotine treatment has been shown to attenuate this effect. Recent studies have demonstrated the importance of DREAM protein in learning and memory processes. This study investigates the association of DREAM protein in REM sleep-deprived rats hippocampus upon nicotine treatment.

METHODS

Male Sprague Dawley rats were subjected to normal condition, REM sleep deprivation and control wide platform condition for 72 hr. During this procedure, saline or nicotine (1 mg/kg) was given subcutaneously twice a day. Then, Morris water maze (MWM) test was used to assess learning and memory performance of the rats. The rats were sacrificed and the brain was harvested for immunohistochemistry and Western blot analysis.

RESULTS

MWM test found that REM sleep deprivation significantly impaired learning and memory performance without defect in locomotor function associated with a significant increase in hippocampus DREAM protein expression in CA1, CA2, CA3, and DG regions and the mean relative level of DREAM protein compared to other experimental groups. Treatment with acute nicotine significantly prevented these effects and decreased expression of DREAM protein in all the hippocampus regions but only slightly reduce the mean relative level of DREAM protein.

CONCLUSION

This study suggests that changes in DREAM protein expression in CA1, CA2, CA3, and DG regions of rat's hippocampus and mean relative level of DREAM protein may involve in the mechanism of nicotine treatment-prevented REM sleep deprivation-induced learning and memory impairment in rats.

摘要

介绍

快速眼动（REM）睡眠剥夺与学习和记忆受损有关，而尼古丁治疗已被证明可以减轻这种影响。最近的研究表明 DREAM 蛋白在学习和记忆过程中的重要性。本研究探讨了 REM 睡眠剥夺大鼠海马体中 DREAM 蛋白与尼古丁治疗的关联。

方法

雄性 Sprague Dawley 大鼠在正常条件、REM 睡眠剥夺和对照宽平台条件下分别处理 72 小时。在此过程中，每天两次皮下给予盐水或尼古丁（1mg/kg）。然后，使用 Morris 水迷宫（MWM）测试来评估大鼠的学习和记忆表现。处死大鼠，采集脑组织进行免疫组织化学和 Western blot 分析。

结果

MWM 测试发现，REM 睡眠剥夺显著损害了学习和记忆能力，但与运动功能缺陷无关，与海马体 CA1、CA2、CA3 和 DG 区 DREAM 蛋白表达显著增加以及与其他实验组相比，DREAM 蛋白的平均相对水平相关。急性尼古丁治疗显著预防了这些影响，并降低了所有海马体区域的 DREAM 蛋白表达，但仅略微降低了 DREAM 蛋白的平均相对水平。

结论

本研究表明，大鼠海马体 CA1、CA2、CA3 和 DG 区 DREAM 蛋白表达和平均相对水平的变化可能涉及尼古丁治疗预防 REM 睡眠剥夺诱导的大鼠学习和记忆损伤的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a039/5474708/fbc0f77d4fb3/BRB3-7-e00704-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a039/5474708/2b673796fc17/BRB3-7-e00704-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a039/5474708/539f1fd1e150/BRB3-7-e00704-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a039/5474708/ba2fcdd6c119/BRB3-7-e00704-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a039/5474708/fbc0f77d4fb3/BRB3-7-e00704-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a039/5474708/2b673796fc17/BRB3-7-e00704-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a039/5474708/539f1fd1e150/BRB3-7-e00704-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a039/5474708/ba2fcdd6c119/BRB3-7-e00704-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a039/5474708/fbc0f77d4fb3/BRB3-7-e00704-g004.jpg

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