National Center of Biotechnology, Consejo Superior de Investigaciones Científicas (CSIC) and the Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28049 Madrid, Spain.
J Biol Chem. 2012 Sep 14;287(38):31674-80. doi: 10.1074/jbc.R112.384982. Epub 2012 Jul 20.
Intracellular free Ca(2+) ions regulate many cellular functions, and in turn, the cell devotes many genes/proteins to keep tight control of the level of intracellular free Ca(2+). Here, we review recent work on Ca(2+)-dependent mechanisms and effectors that regulate the transcription of genes encoding proteins involved in the maintenance of the homeostasis of Ca(2+) in the cell.
细胞内游离 Ca(2+) 离子调节许多细胞功能,反过来,细胞也投入许多基因/蛋白来严格控制细胞内游离 Ca(2+) 的水平。在这里,我们综述了最近关于依赖 Ca(2+) 的机制和效应物的研究,这些机制和效应物调节编码参与细胞内 Ca(2+) 稳态维持的蛋白的基因的转录。