Sugimoto Mitsuru, Takagi Tadayuki, Suzuki Rei, Konno Naoki, Asama Hiroyuki, Watanabe Ko, Nakamura Jun, Kikuchi Hitomi, Waragai Yuichi, Takasumi Mika, Kawana Satoshi, Hashimoto Yuko, Hikichi Takuto, Ohira Hiromasa
Mitsuru Sugimoto, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Yuichi Waragai, Mika Takasumi, Hiromasa Ohira, Department of Gastroenterology, Fukushima Medical University, School of Medicine, Fukushima City, Fukushima Prefecture 960-1295, Japan.
World J Clin Oncol. 2017 Jun 10;8(3):293-299. doi: 10.5306/wjco.v8.i3.293.
Among the three grades of neuroendocrine tumors (NETs), the prognosis for Grade 1 (G1) with surgery is very good. Therefore, we evaluated the prognoses of pancreatic NET (PNET) G1 patients without surgery. A total of 8 patients who were diagnosed with NET G1, with an observation period of more than 6 mo until surgery or without surgery, were recruited. The patients who underwent surgery were ultimately diagnosed using specimens obtained during the surgery, whereas the patients who did not undergo surgery were diagnosed using specimens obtained by endoscopic ultrasonography-guided fine needle aspiration. Overall, we mainly evaluated the observation period and tumor growth. The observation period for the five cases with surgery ranged from 6-80 mo, and tumor growth was observed in one case. In contrast, the observation period for the three cases without surgery ranged from 17-54 mo, and tumor growth was not observed. Therefore, although the first-choice treatment for NETs is surgery, our experience includes certain NET G1 patients who were followed up without surgery.
在神经内分泌肿瘤（NETs）的三个分级中，1级（G1）手术患者的预后非常好。因此，我们评估了未接受手术的胰腺NET（PNET）G1患者的预后。共招募了8例诊断为NET G1的患者，观察期超过6个月直至手术或未接受手术。接受手术的患者最终通过手术中获取的标本确诊，而未接受手术的患者则通过内镜超声引导下细针穿刺获取的标本确诊。总体而言，我们主要评估观察期和肿瘤生长情况。5例接受手术患者的观察期为6 - 80个月，其中1例观察到肿瘤生长。相比之下，3例未接受手术患者的观察期为17 - 54个月，未观察到肿瘤生长。因此，尽管NETs的首选治疗方法是手术，但我们的经验包括某些未接受手术而进行随访的NET G1患者。
