Brown D F, Bellamy R F
Toxicol Lett. 1985 Aug;26(2-3):127-32. doi: 10.1016/0378-4274(85)90156-0.
The effect of WR 149024, an alpha-receptor antagonist, on survival following hemorrhage with no volume replacement therapy, was investigated. WR 149024 (either 5.0 or 50.0 mg/kg) was administered intraperitoneally (i.p.) to conscious rats during exsanguination. Both WR 149024 treatments caused a significant decrease in survival (P less than 0.021), compared with water-injected controls.
研究了α受体拮抗剂WR 149024在无容量替代治疗的出血后对存活的影响。在放血过程中，将WR 149024（5.0或50.0毫克/千克）腹腔注射（i.p.）给清醒的大鼠。与注射水的对照组相比，两种WR 149024处理均导致存活率显著降低（P小于0.021）。
