Coccia M T, Waxman K, Soliman M H, Tominaga G, Pinderski L
Department of Surgery, University of California, Irvine Medical Center, Orange 92668.
Crit Care Med. 1989 Jan;17(1):36-8. doi: 10.1097/00003246-198901000-00009.
Pentoxifylline is an agent which improves microcirculatory blood flow, but its use as therapy for shock has not been reported. We performed this study to determine if pentoxifylline improves survival following experimental hemorrhagic shock. Anesthetized Sprague-Dawley rats were studied; the animals were subjected to hemorrhage and then resuscitated using lactated Ringer's solution, with either placebo or pentoxifylline added by random selecting. Animals were then observed for 3 days. There was significantly increased survival in pentoxifylline-treated animals (p less than .05). In additional experiments, animals received more aggressive fluid resuscitation; improved survival in the pentoxifylline group was noted almost immediately and persisted through the 72-h period. This was significant at the p less than .01 level. We conclude that pentoxifylline improves survival from hemorrhagic shock in this experimental model, and has additive survival value to fluid resuscitation.
己酮可可碱是一种能改善微循环血流的药物，但尚未有将其用于休克治疗的报道。我们开展这项研究以确定己酮可可碱能否提高实验性失血性休克后的存活率。对麻醉后的斯普拉格-道利大鼠进行研究；使动物出血，然后用乳酸林格液进行复苏，通过随机选择添加安慰剂或己酮可可碱。随后对动物观察3天。己酮可可碱治疗组动物的存活率显著提高（p小于0.05）。在另外的实验中，动物接受了更积极的液体复苏；己酮可可碱组的存活率几乎立即得到改善，并持续至72小时。这在p小于0.01水平具有显著性。我们得出结论，在这个实验模型中己酮可可碱可提高失血性休克后的存活率，并且对液体复苏具有额外的存活价值。
