男男性行为的人类免疫缺陷病毒感染者中丙型肝炎病毒感染的自发清除
Spontaneous Clearance of Hepatitis C Virus Infection Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men.
作者信息
Newsum Astrid M, Schinkel Janke, van de Laar Thijs J W, van der Meer Jan T M, Prins Maria
机构信息
Department of Infectious Diseases Research and Prevention, Public Health Service of Amsterdam.
Department of Internal Medicine, Center for Infection and Immunity Amsterdam (CINIMA), and.
出版信息
Open Forum Infect Dis. 2017 Jun 16;4(2):ofx090. doi: 10.1093/ofid/ofx090. eCollection 2017 Spring.
Abstract
We assessed spontaneous clearance in 27 human immunodeficiency virus-infected men who have sex with men (MSM) who seroconverted for hepatitis C virus (HCV). In contrast with a recent estimate of 45.8%, we found a spontaneous clearance rate of 11.1% (95% confidence interval = 2.4-29.2). This finding suggests that treatment deferral to await spontaneous clearance might not be justified for MSM with sexually acquired HCV.
摘要
我们评估了27名感染人类免疫缺陷病毒且与男性发生性行为的男性（男男性行为者）的丙型肝炎病毒（HCV）血清转换后的自发清除情况。与最近估计的45.8%相比，我们发现自发清除率为11.1%（95%置信区间 = 2.4 - 29.2）。这一发现表明，对于通过性传播感染HCV的男男性行为者，等待自发清除而推迟治疗可能不合理。
相似文献
1
Spontaneous Clearance of Hepatitis C Virus Infection Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men.男男性行为的人类免疫缺陷病毒感染者中丙型肝炎病毒感染的自发清除
Open Forum Infect Dis. 2017 Jun 16;4(2):ofx090. doi: 10.1093/ofid/ofx090. eCollection 2017 Spring.
2
Spontaneous Clearance of the Hepatitis C Virus Among Men Who Have Sex With Men.男男性行为者中丙型肝炎病毒的自发清除
Clin Infect Dis. 2015 Nov 1;61(9):1381-8. doi: 10.1093/cid/civ562. Epub 2015 Jul 14.
3
Spontaneous viral clearance of hepatitis C virus (HCV) infection among people who inject drugs (PWID) and HIV-positive men who have sex with men (HIV+ MSM): a systematic review and meta-analysis.注射吸毒者（PWID）和男男性行为艾滋病毒阳性者（HIV+ MSM）中丙型肝炎病毒（HCV）感染的自发病毒清除：一项系统评价和荟萃分析。
BMC Infect Dis. 2016 Sep 5;16(1):471. doi: 10.1186/s12879-016-1807-5.
4
Correlates of spontaneous clearance of hepatitis C virus in a Danish human immunodeficiency virus type 1 cohort.丹麦1型人类免疫缺陷病毒队列中丙型肝炎病毒自发清除的相关因素
Scand J Infect Dis. 2011 Oct;43(10):798-803. doi: 10.3109/00365548.2011.589077. Epub 2011 Jul 5.
5
Risk Factors for Sexual Transmission of Hepatitis C Virus Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men: A Case-Control Study.男男性行为人群中感染人类免疫缺陷病毒的男性经性传播丙型肝炎病毒的风险因素：一项病例对照研究。
Open Forum Infect Dis. 2015 Aug 6;2(3):ofv115. doi: 10.1093/ofid/ofv115. eCollection 2015 Sep.
6
Rapid decline of anti-hepatitis C virus (HCV) antibodies following early treatment of incident HCV infections in HIV-infected men who have sex with men.感染 HIV 的男男性行为者发生 HCV 感染后早期治疗，其抗 HCV 抗体迅速下降。
HIV Med. 2018 Jul;19(6):420-425. doi: 10.1111/hiv.12602. Epub 2018 Mar 24.
7
HIV-positive men who have sex with men are at high risk of development of significant liver fibrosis after an episode of acute hepatitis C.与男性发生性行为的艾滋病毒呈阳性者在急性丙型肝炎发作后发生显著肝纤维化的风险很高。
J Viral Hepat. 2017 Oct;24(10):832-839. doi: 10.1111/jvh.12707. Epub 2017 Apr 25.
8
Multiple hepatitis C virus (HCV) reinfections in HIV-positive men who have sex with men: no influence of HCV genotype switch or interleukin-28B genotype on spontaneous clearance.男男性行为的HIV阳性者中丙型肝炎病毒（HCV）的多次再感染：HCV基因型转换或白细胞介素-28B基因型对自发清除无影响。
HIV Med. 2014 Jul;15(6):355-61. doi: 10.1111/hiv.12127. Epub 2014 Feb 24.
9
Earlier Detection of Hepatitis C Virus Infection Through Routine Hepatitis C Virus Antibody Screening of Human Immunodeficiency Virus-Positive Men Who Have Sex With Men Attending A Sexually Transmitted Infection Outpatient Clinic: A Longitudinal Study.通过对一家性传播感染门诊就诊的感染人类免疫缺陷病毒的男同性恋者进行常规丙型肝炎病毒抗体筛查来早期检测丙型肝炎病毒感染：一项纵向研究
Sex Transm Dis. 2016 Sep;43(9):560-5. doi: 10.1097/OLQ.0000000000000497.
10
Shedding of Hepatitis C Virus in Semen of Human Immunodeficiency Virus-Infected Men.人类免疫缺陷病毒感染男性精液中丙型肝炎病毒的脱落。
Open Forum Infect Dis. 2016 Mar 11;3(2):ofw057. doi: 10.1093/ofid/ofw057. eCollection 2016 Mar.
引用本文的文献
1
Hepatitis C virus testing in infants, a move to early screening by HCV RNA at 2 months of age.婴儿丙型肝炎病毒检测，一项在2月龄时通过丙型肝炎病毒核糖核酸进行早期筛查的举措。
Paediatr Child Health. 2025 May 8;30(5):373-378. doi: 10.1093/pch/pxaf012. eCollection 2025 Aug.
2
Incidence of hepatitis C virus infection and associated determinants among men who have sex with men without HIV in Amsterdam, the Netherlands, between 2012 and 2021.2012年至2021年期间，荷兰阿姆斯特丹未感染艾滋病毒的男男性行为者中丙型肝炎病毒感染的发病率及相关决定因素。
Eur J Gastroenterol Hepatol. 2025 Oct 1;37(10):1173-1179. doi: 10.1097/MEG.0000000000003008. Epub 2025 Jun 23.
3
Modeling Combination Hepatitis C Virus Treatment and Prevention Strategies in a Network of People Who Inject Drugs in the United States.在美国的注射吸毒者网络中对丙型肝炎病毒治疗和预防策略进行建模。
Clin Infect Dis. 2021 Mar 1;72(5):755-763. doi: 10.1093/cid/ciaa142.
4
Sociodemographic and clinical characteristics of persons who experienced spontaneous hepatitis C viral clearance.自发性丙型肝炎病毒清除者的社会人口学和临床特征。
BMC Infect Dis. 2019 Jul 15;19(1):626. doi: 10.1186/s12879-019-4223-9.
本文引用的文献
1
Spontaneous viral clearance of hepatitis C virus (HCV) infection among people who inject drugs (PWID) and HIV-positive men who have sex with men (HIV+ MSM): a systematic review and meta-analysis.注射吸毒者（PWID）和男男性行为艾滋病毒阳性者（HIV+ MSM）中丙型肝炎病毒（HCV）感染的自发病毒清除：一项系统评价和荟萃分析。
BMC Infect Dis. 2016 Sep 5;16(1):471. doi: 10.1186/s12879-016-1807-5.
2
Factors associated with spontaneous clearance of chronic hepatitis C virus infection.与慢性丙型肝炎病毒感染自发清除相关的因素。
J Hepatol. 2016 Aug;65(2):266-72. doi: 10.1016/j.jhep.2016.04.030. Epub 2016 May 4.
3
Can Hepatitis C Virus (HCV) Direct-Acting Antiviral Treatment as Prevention Reverse the HCV Epidemic Among Men Who Have Sex With Men in the United Kingdom? Epidemiological and Modeling Insights.丙型肝炎病毒（HCV）直接抗病毒治疗作为预防措施能否扭转英国男男性行为者中的丙型肝炎病毒流行态势？流行病学与建模见解。
Clin Infect Dis. 2016 May 1;62(9):1072-1080. doi: 10.1093/cid/ciw075. Epub 2016 Feb 16.
4
Incidence of sexually transmitted hepatitis C virus infection in HIV-positive men who have sex with men.男男性行为的HIV阳性者中丙型肝炎病毒性传播感染的发病率。
AIDS. 2015 Nov;29(17):2335-45. doi: 10.1097/QAD.0000000000000834.
5
Spontaneous Clearance of the Hepatitis C Virus Among Men Who Have Sex With Men.男男性行为者中丙型肝炎病毒的自发清除
Clin Infect Dis. 2015 Nov 1;61(9):1381-8. doi: 10.1093/cid/civ562. Epub 2015 Jul 14.
6
Stabilizing incidence of hepatitis C virus infection among men who have sex with men in Amsterdam.阿姆斯特丹男男性行为者中丙型肝炎病毒感染发病率趋于稳定。
J Acquir Immune Defic Syndr. 2014 Aug 15;66(5):e111-5. doi: 10.1097/QAI.0000000000000208.
7
The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection.女性性别、病毒基因型和 IL28B 基因型对急性丙型肝炎病毒感染自发清除的影响。
Hepatology. 2014 Jan;59(1):109-20. doi: 10.1002/hep.26639. Epub 2013 Nov 22.
8
Incident hepatitis C virus infection in men who have sex with men: a prospective cohort analysis, 1984-2011.男男性行为者中的丙型肝炎病毒感染事件：一项前瞻性队列分析，1984-2011 年。
Clin Infect Dis. 2013 Jul;57(1):77-84. doi: 10.1093/cid/cit197. Epub 2013 Mar 26.
9
High prevalence of sexually transmitted infections in HIV-infected men during routine outpatient visits in the Netherlands.荷兰门诊就诊的 HIV 感染男性中性传播感染的高发率。
Sex Transm Dis. 2012 Jan;39(1):8-15. doi: 10.1097/OLQ.0b013e3182354e81.
10
Female sex and IL28B, a synergism for spontaneous viral clearance in hepatitis C virus (HCV) seroconverters from a community-based cohort.女性性别和 IL28B，是社区为基础队列丙型肝炎病毒 (HCV) 血清转换者自发病毒清除的协同作用因素。
PLoS One. 2011;6(11):e27555. doi: 10.1371/journal.pone.0027555. Epub 2011 Nov 15.
Zotero 插件