Tudesq Jean-Jacques, Vincent Laure, Lebrun Julie, Hicheri Yosr, Gabellier Ludovic, Busetto Timothé, Merle Corinne, Fegueux Nathalie, Ceballos Patrice, Quittet Philippe, Navarro Robert, Hillaire-Buys Dominique, Cartron Guillaume
Département d'Hématologie Clinique.
Département de Réanimation Médicale et des Brûlés.
Open Forum Infect Dis. 2017 Apr 5;4(2):ofx091. doi: 10.1093/ofid/ofx091. eCollection 2017 Spring.
Brentuximab vedotin is an antibody-conjugated chemotherapy targeting CD30 indicated in treatment of several lymphomas. We report the first 3 cases of cytomegalovirus severe infections with retinitis following this treatment. Evolution was favorable, but relapse occurred after treatment rechallenge. We suggest vigilance about cytomegalovirus in patients treated with brentuximab vedotin.
本妥昔单抗是一种靶向CD30的抗体偶联化疗药物，用于治疗多种淋巴瘤。我们报告了首例接受该治疗后发生巨细胞病毒严重感染并伴有视网膜炎的3例病例。病情进展良好，但再次治疗后复发。我们建议对接受本妥昔单抗治疗的患者警惕巨细胞病毒感染。
