线粒体和 FOXO3 在干细胞稳态中的作用，揭示了造血干细胞命运决定的机制。
Mitochondria and FOXO3 in stem cell homeostasis, a window into hematopoietic stem cell fate determination.
机构信息
Department of Cell, Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Developmental and Stem Cell Biology Multidisciplinary Training Area, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
出版信息
J Bioenerg Biomembr. 2017 Aug;49(4):343-346. doi: 10.1007/s10863-017-9719-7. Epub 2017 Jun 21.
Abstract
The production of all blood cells from hematopoietic stem cells (HSC) is highly sensitive to reactive oxygen species (ROS). Cumulating evidence suggests that mitochondria are critical for HSC fate determination. FOXO are known regulators of anti-oxidant response and key to the maintenance of HSC. Recent works indicate that FOXO3 is implicated in the control of mitochondrial function beyond regulating levels of ROS in HSC. Here we review these findings and discuss implications for homeostatic blood formation and stem cell fate determination.
摘要
造血干细胞（HSC）产生所有血细胞的过程对活性氧（ROS）极为敏感。越来越多的证据表明，线粒体对于 HSC 命运的决定至关重要。FOXO 是抗氧化反应的已知调节剂，也是维持 HSC 的关键。最近的研究表明，FOXO3 不仅通过调节 HSC 中的 ROS 水平来控制线粒体功能，而且还与控制线粒体功能有关。在这里，我们回顾这些发现，并讨论其对血液形成和干细胞命运决定的稳态的影响。
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