Alonso-Castro Angel Josabad, Rangel-Velázquez Joceline Estefanía, Isiordia-Espinoza Mario A, Villanueva-Solís Luis Enrique, Aragon-Martinez Othoniel H, Zapata-Morales Juan Ramón
Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, CP, 36050, México (Gto).
Departamento de Investigación, Escuela de Odontología, Universidad Cuauhtémoc, San Luis Potosí, México.
Drug Dev Res. 2017 Aug;78(5):184-188. doi: 10.1002/ddr.21391. Epub 2017 Jun 22.
Preclinical Research The aim of the present study was to evaluate the antinociceptive interaction between naproxen and the glycoside flavonoid, rutin in the acetic acid-induced writhing test in mice. Naproxen (5, 20, 50, and 100 mg/kg p.o.) or rutin (10, 25, 50, and 100mg/kg p.o.) were administered 60 min before the intraperitoneal administration with acetic acid. The dose-response curve of each individual compound and the experimental effective dose 50 (ED ) value were obtained to determinate different proportions of the combinations between the two compounds (naproxen-rutin 1:1, 3:1, and 3:1) in the writhing test. The results indicated a synergistic antinociceptive interaction between two drugs with different mechanism of action, naproxen and rutin in all the combinations. Drug Dev Res 78 : 184-188, 2017. © 2017 Wiley Periodicals, Inc.
临床前研究 本研究的目的是在小鼠醋酸诱导扭体试验中评估萘普生与糖苷类黄酮芦丁之间的镇痛相互作用。在腹腔注射醋酸前60分钟口服给予萘普生（5、20、50和100毫克/千克）或芦丁（10、25、50和100毫克/千克）。获得每种单独化合物的剂量-反应曲线和实验半数有效剂量（ED）值，以确定在扭体试验中两种化合物（萘普生-芦丁1:1、3:1和3:1）不同比例的组合。结果表明，在所有组合中，作用机制不同的两种药物萘普生和芦丁之间存在协同镇痛相互作用。《药物研发研究》78: 184 - 188，2017年。©2017威利期刊公司。
