Shrivastava Manisha, Nehal Shah, Seema Navaid
Department of Transfusion Medicine, Bhopal Memorial Hospital & Research Centre, Bhopal, India.
Department of Physiotherapy, Bhopal Memorial Hospital & Research Centre, Bhopal, India.
Indian J Med Res. 2017 Feb;145(2):203-208. doi: 10.4103/ijmr.IJMR_995_14.
BACKGROUND & OBJECTIVES: Guillain-Barre syndrome (GBS) is an autoimmune disease and a recognized cause of generalized progressive paralysis worldwide. The present study was aimed to document the clinical findings, demographics and seasonal variations amongst the patients with GBS during the hospital stay.
A retrospective analysis of 66 referred cases diagnosed as GBS was conducted. Medical records and the data related to age, sex, antecedent illness, duration of symptoms before admission, muscle power graded by the Medical Research Council scale, functional scores, details of Intensive Care Unit complications and need for ventilation were obtained. The patients were divided into four seasonal groups: S1 (spring, February to April), S2 (summer, May to July), S3 (rainy, August to October) and S4 (winter, November to January) and parameters were studied.
The mean age of the patients was 40.69 yr. Forty one (62.1%) patients had a history of preceding illness. Forty nine (74.2%) patients showed quadriparesis as most common complaint. Thirty three (50%) patients were of acute inflammatory demyelinating polyneuropathy (AIDP) variant. The highest number of GBS cases (60%) was found in S1 and S2. The maximum duration of hospital stay was observed in S3 group (mean 23 days).
INTERPRETATION & CONCLUSIONS: GBS seems to affect all age groups with male preponderance. Most common antecedent event and presenting feature were flu-like illness and quadriparesis, respectively. AIDP was the most common variant. Most cases occurred from February to July (S1 and S2 group) (maximum in July) with preceding influenza and diarrhoea and maximum duration of hospital stay was observed in S3 group. Prospective studies with follow up of GBS patients need to be done to confirm findings.
吉兰-巴雷综合征（GBS）是一种自身免疫性疾病，是全球公认的导致全身进行性麻痹的病因。本研究旨在记录GBS患者住院期间的临床症状、人口统计学特征和季节变化。
对66例确诊为GBS的转诊病例进行回顾性分析。获取病历以及与年龄、性别、前驱疾病、入院前症状持续时间、医学研究委员会量表评定的肌力、功能评分、重症监护病房并发症细节和通气需求相关的数据。将患者分为四个季节组：S1（春季，2月至4月）、S2（夏季，5月至7月）、S3（雨季，8月至10月）和S4（冬季，11月至1月），并对各项参数进行研究。
患者的平均年龄为40.69岁。41例（62.1%）患者有前驱疾病史。49例（74.2%）患者以四肢瘫为最常见主诉。33例（50%）患者为急性炎症性脱髓鞘性多发性神经病（AIDP）型。GBS病例数最多（60%）出现在S1和S2组。住院时间最长的是S3组（平均23天）。
GBS似乎影响所有年龄组，男性居多。最常见的前驱事件和临床表现分别是流感样疾病和四肢瘫。AIDP是最常见的类型。大多数病例发生在2月至7月（S1和S2组）（7月最多），前驱症状为流感和腹泻，住院时间最长的是S3组。需要对GBS患者进行前瞻性随访研究以证实这些发现。
