McGrogan Anita, Madle Gemma C, Seaman Helen E, de Vries Corinne S
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.
Neuroepidemiology. 2009;32(2):150-63. doi: 10.1159/000184748. Epub 2008 Dec 17.
This systematic literature review of the epidemiology of Guillain-Barré syndrome (GBS) identifies trends in incidence rates by age, study method and cause of disease. It is important to have a reliable estimate of incidence to determine and investigate any changes: no previous systematic reviews of GBS have been found.
After critical assessment of the reliability of the reported data, incidence rates were extracted from all relevant papers published between 1980 and 2008, identified through searches of Medline, Embase and Science Direct.
Sixty-three papers were included in this review; these studies were prospective, retrospective reviews of medical records or retrospective database studies. Ten studies reported on the incidence in children (0-15 years old), and found the annual incidence to be between 0.34 and 1.34/100,000. Most studies investigated populations in Europe and North America and reported similar annual incidence rates, i.e. between 0.84 and 1.91/100,000. A decrease in incidence over the time between the 1980s and 1990s was found. Up to 70% of cases of GBS were caused by antecedent infections.
Our best estimate of the overall incidence of GBS was between 1.1/100,000/year and 1.8/100,000/year. The incidence of GBS increased with age after 50 years from 1.7/100,000/year to 3.3/100,000/year.
这项关于吉兰-巴雷综合征（GBS）流行病学的系统文献综述确定了发病率在年龄、研究方法和病因方面的趋势。对发病率进行可靠估计对于确定和调查任何变化很重要：此前未发现对GBS的系统综述。
在对报告数据的可靠性进行严格评估后，从通过检索Medline、Embase和Science Direct所确定的1980年至2008年发表的所有相关论文中提取发病率。
本综述纳入了63篇论文；这些研究为前瞻性研究、病历回顾性研究或数据库回顾性研究。10项研究报告了儿童（0至15岁）的发病率，发现年发病率在0.34至1.34/10万之间。大多数研究调查了欧洲和北美的人群，报告的年发病率相似，即0.84至1.91/10万之间。发现20世纪80年代至90年代期间发病率有所下降。高达70%的GBS病例由前驱感染引起。
我们对GBS总体发病率的最佳估计为每年1.1/10万至1.8/10万。50岁以后GBS的发病率随年龄增长，从每年1.7/10万增至3.3/10万。
