Rouiller Nathalie, Jornayvaz François R
Service d'endocrinologie, diabétologie et métabolisme, CHUV, 1011 Lausanne.
Service d'endocrinologie, diabétologie, hypertension et nutrition, HUG, 1211 Genève 14.
Rev Med Suisse. 2017 May 31;13(565):1158-1162.
An endocrine disease can be associated with glucose intolerance or diabetes mellitus, and the latter can falsely be considered as type 2 diabetes. Glycemic imbalance can be a direct or indirect consequence of excessive hormone production. Endocrine diseases such as acromegaly, Cushing's syndrome and pheochromocytoma can increase glucose production and cause insulin resistance. Hyperthyroidism, hyperaldosteronism, glucagonoma and somatostatinoma lead to hyperglycemia by other physiopathological mechanisms detailed in this article. When a clinical picture suggests an endocrine disease, several analyses need to be done in order to avoid treatment escalation of diabetes.
一种内分泌疾病可能与葡萄糖耐量异常或糖尿病相关，而后者可能会被错误地认为是2型糖尿病。血糖失衡可能是激素分泌过多的直接或间接后果。肢端肥大症、库欣综合征和嗜铬细胞瘤等内分泌疾病可增加葡萄糖生成并导致胰岛素抵抗。甲状腺功能亢进症、醛固酮增多症、胰高血糖素瘤和生长抑素瘤通过本文详述的其他生理病理机制导致高血糖。当临床表现提示存在内分泌疾病时，需要进行多项分析，以避免糖尿病治疗的过度升级。
