Sell Stewart
Wadsworth Center, New York State Department of Health and Albany College of Pharmacy and Health Sciences, Albany, NY, USA.
Tumour Biol. 2017 Jun;39(6):1010428317707764. doi: 10.1177/1010428317707764.
From the application of Coley's toxin in the early 1900s to the present clinical trials using immune checkpoint regulatory inhibitors, the history of cancer immunotherapy has consisted of extremely high levels of enthusiasm after anecdotal case reports of enormous success, followed by decreasing levels of enthusiasm as the results of controlled clinical trials are available. In this review, this pattern will be documented for the various immunotherapeutic approaches over the years. The sole exception being vaccination against cancer causing viruses, which have already prevented thousands of cancers. We can only hope that the present high level of enthusiasm for the use of immune stimulation by removal of blocks to cancer immunity will be more productive than the incremental improvements using previous immunotherapies.
从20世纪初科利毒素的应用到目前使用免疫检查点调节抑制剂的临床试验，癌症免疫治疗的历史呈现出这样一种模式：在个别病例取得巨大成功的报道之后，人们会极度热情高涨，而随着对照临床试验结果的公布，热情又会逐渐消退。在这篇综述中，将会记录多年来各种免疫治疗方法的这种模式。唯一的例外是针对致癌病毒的疫苗接种，这种疫苗已经预防了数千例癌症。我们只能希望，目前通过消除癌症免疫障碍来利用免疫刺激的高度热情，会比以往免疫治疗的渐进式改进更有成效。
