Efe Tolga Han, Doğan Mehmet, Özişler Cem, Çimen Tolga, Felekoğlu Mehmet Ali, Ertem Ahmet Göktuğ, Algül Engin, Açıkel Sadık
Department of Cardiology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital; Ankara-Turkey.
Anatol J Cardiol. 2017 Sep;18(3):223-228. doi: 10.14744/AnatolJCardiol.2017.7666. Epub 2017 Jun 22.
Systemic lupus erythematosus (SLE) is a chronic, inflammatory, and autoimmune connective tissue disease. One of the leading causes of mortality among SLE patients is pulmonary hypertension. The aim of this study was to evaluate the association between echocardiographic findings, including the pulmonary pulse transit time and pulmonary hypertension parameters, in SLE patients.
Thirty SLE patients (aged 39.9±11 years, 28 females) as the study group and 34 age- and sex-matched healthy volunteers (aged 37.9±11.5 years, 31 females) as the control group were included in the study. After detailed medical histories were recorded, 12-lead electrocardiography, blood tests, and echocardiography were performed in the groups. In addition to basic echocardiographic measurements, other specialized right ventricular indicators [i.e, Tricuspid Annular Plane Systolic Excursion (TAPSE), estimated pulmonary artery systolic pressure (ePASP), right ventricular dimensions, and myocardial performance index (MPI)] were measured. The pulmonary pulse transit time was defined as the time interval between the R-wave peak in ECG and the corresponding peak late-systolic pulmonary vein flow velocity.
The mean disease duration was 121.1±49.9 months. The mean age at diagnosis was 35.0±15.4 years. The mean RV MPI was higher (p=0.026), mean TAPSE measurements were shorter (p=0.021), and mean ePASP was higher (p=0.036) in the SLE group than in the control group. In addition, pPTT was significantly shorter in the SLE group (p=0.003). pPTT was inversely correlated with disease duration (p<0.001), MPI (p=0.037), and ePASP (p=0.02) and positively correlated with TAPSE (p<0.001).
SLE patients have higher pPTT values than controls. Further, pPTT shows an inverse correlation with disease duration, MPI, and ePASP and a positive correlation with TAPSE.
系统性红斑狼疮（SLE）是一种慢性、炎症性自身免疫性结缔组织病。SLE患者死亡的主要原因之一是肺动脉高压。本研究旨在评估SLE患者超声心动图检查结果之间的关联，包括肺脉搏传输时间和肺动脉高压参数。
本研究纳入30例SLE患者（年龄39.9±11岁，女性28例）作为研究组，以及34例年龄和性别匹配的健康志愿者（年龄37.9±11.5岁，女性31例）作为对照组。记录详细病史后，对两组进行12导联心电图、血液检查和超声心动图检查。除了基本的超声心动图测量外，还测量了其他专门的右心室指标[即三尖瓣环平面收缩期位移（TAPSE）、估计肺动脉收缩压（ePASP）、右心室尺寸和心肌性能指数（MPI）]。肺脉搏传输时间定义为心电图中R波峰值与相应的晚期收缩期肺静脉血流速度峰值之间的时间间隔。
平均病程为121.1±49.9个月。诊断时的平均年龄为35.0±15.4岁。SLE组的平均右心室MPI较高（p = 0.026），平均TAPSE测量值较短（p = 0.021），平均ePASP较高（p = 0.036），均高于对照组。此外，SLE组的pPTT明显较短（p = 0.003）。pPTT与病程（p < 0.001）、MPI（p = 0.037）和ePASP（p = 0.02）呈负相关，与TAPSE呈正相关（p < 0.001）。
SLE患者的pPTT值高于对照组。此外，pPTT与病程、MPI和ePASP呈负相关，与TAPSE呈正相关。
