Jiang Yu-Feng, Chen Min, Zhang Nan-Nan, Yang Hua-Jia, Xu Lang-Biao, Rui Qing, Sun Si-Jia, Yao Jia-Lu, Zhou Ya-Feng
Department of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou City Department of Cardiology, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Jiangsu Province, P. R. China.
Medicine (Baltimore). 2017 Jun;96(25):e7253. doi: 10.1097/MD.0000000000007253.
Previous case-control studies on association between KCNE1 G38S polymorphism and risk of atrial fibrillation (AF) have been published but because of the conflicting results and small sample size of individual studies, the consolidated result is still controversial.
The aim of this study was to explore the relationship between KCNE1 G38S polymorphism and risk of AF.
We performed a comprehensive literature search on PubMed, Embase, OVID, Web of Science, Wan Fang, and CNKI databases up to March 10, 2017 in English and Chinese languages. Two of the authors individually extracted study data and assessed the study quality using Newcastle-Ottawa scale. Odds ratios (ORs) and 95% confidence intervals (CIs) were combined in different genetic models for evaluation using a random-effect model or fixed-effect model according to interstudy heterogeneity.
There were totally 14 independent case-control studies of 2810 patients and 3080 healthy controls included. Significant associations were found between KCNE1 G38S polymorphism and AF in overall population under all genetic models: allelic (OR: 1.34, 95% CI: 1.24-1.45, P < .001), homozygous (OR: 1.90, 95% CI: 1.61-2.24, P < .001), heterozygous (OR: 1.43, 95% CI: 1.21-1.68, P < .001), recessive (OR: 1.42, 95% CI: 1.20-1.69, P < .001), dominant genetic model (OR: 1.62, 95% CI: 1.39-1.89, P < .001). Subgroup analyses indicated similar association in Chinese and white.
The G38S polymorphism in the KCNE1 gene can significantly increase the risk of AF in both Chinese and white.
此前已有关于KCNE1基因G38S多态性与房颤（AF）风险之间关联的病例对照研究发表，但由于各研究结果相互矛盾且样本量较小，综合结果仍存在争议。
本研究旨在探讨KCNE1基因G38S多态性与房颤风险之间的关系。
截至2017年3月10日，我们在PubMed、Embase、OVID、Web of Science、万方和知网数据库中进行了全面的中英文文献检索。两位作者分别提取研究数据，并使用纽卡斯尔-渥太华量表评估研究质量。根据研究间的异质性，采用随机效应模型或固定效应模型，在不同遗传模型中合并比值比（OR）和95%置信区间（CI）进行评估。
共纳入2810例患者和3080例健康对照的14项独立病例对照研究。在所有遗传模型下，总体人群中KCNE1基因G38S多态性与房颤之间均存在显著关联：等位基因（OR：1.34，95%CI：1.24 - 1.45，P <.001）、纯合子（OR：1.90，95%CI：1.61 - 2.24，P <.001）、杂合子（OR：1.43，95%CI：1.21 - 1.68，P <.001）、隐性遗传模型（OR：1.42，95%CI：1.20 - 1.69，P <.001）、显性遗传模型（OR：1.62，95%CI：1.39 - 1.89，P <.001）。亚组分析表明中国人群和白种人群中的关联相似。
KCNE1基因的G38S多态性可显著增加中国人群和白种人群患房颤的风险。
