KCNE1（G38S）基因多态性与维吾尔族人群中非瓣膜性心房颤动的关系。
Association between KCNE1 (G38S) genetic polymorphism and non-valvular atrial fibrillation in an Uygur population.
机构信息
The Cardiac Pacing and Electrophysiological Division, The first teaching hospital of Xinjiang Medical University, 830054 Urumqi, China.
出版信息
Wien Klin Wochenschr. 2012 Nov;124(21-22):737-41. doi: 10.1007/s00508-012-0245-7. Epub 2012 Nov 6.
BACKGROUND
The relationship between KCNE1 G38S genetic polymorphism and non-valvular atrial fibrillation is different among different populations. The study explored the KCNE1 G38S to understand if the KCNE1 G38S is associated with the Uygur atrial fibrillation patients.
METHODS
KCNE1 G38S genetic polymorphism was determined between 237 non-valvular atrial fibrillation cases and 237 control subjects using PCR-RFLP.
RESULTS
In univariate analyses, there was a statistical difference in genotype distribution between the patients and controls, and a significant difference in allele frequency of KCNE1 G38S was observed between the two groups (62.6 vs 52.7 %, p = 0.003). In multivariate analyses, the KCNE1 38G variant was independently associated with a significant predisposing effect on AF after adjusting for related risk factors, and the odds ratio for patients was 1.634 (95 % CI: 1.192-2.240, p = 0.002).
CONCLUSION
The KCNE1 38G is a risk factor for incident AF in an Uygur population. The KCNE1 G38S might have different impact on AF in different ethnicities.
背景
KCNE1 G38S 基因多态性与非瓣膜性心房颤动的关系在不同人群中存在差异。本研究旨在探讨 KCNE1 G38S 与维吾尔族心房颤动患者的关系。
方法
采用 PCR-RFLP 法检测 237 例非瓣膜性心房颤动患者和 237 例对照者的 KCNE1 G38S 基因多态性。
结果
单因素分析显示，患者组与对照组在基因型分布上存在统计学差异，两组间 KCNE1 G38S 等位基因频率也存在显著差异（62.6%比 52.7%，p=0.003）。多因素分析显示，校正相关危险因素后，KCNE1 38G 变异与 AF 的发生显著相关，患者的比值比为 1.634（95%CI：1.192-2.240，p=0.002）。
结论
KCNE1 38G 是维吾尔族人群发生 AF 的危险因素。KCNE1 G38S 对不同种族的 AF 可能有不同的影响。
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