首次生育时间与年龄相关性白内障

Timing of first childbirth and age-related cataract.

作者信息

Park Sangshin, Choi Nam-Kyong

机构信息

1Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 2Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, RI 3Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea 4Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 5Department of Health Convergence, Ewha Womans University, Seoul, Republic of Korea.

出版信息

Menopause. 2017 Sep;24(9):996-1002. doi: 10.1097/GME.0000000000000887.

DOI:10.1097/GME.0000000000000887

PMID:28640167

Abstract

OBJECTIVE

No studies investigated the effects of age at first childbirth on cataract formation. This study was performed to determine the relationships of age at first childbirth to age-related cataract in postmenopausal women.

METHODS

Study population included 7,021 postmenopausal women in the Korea National Health and Nutrition Examination Survey, 2008 to 2012. Participants were subdivided in quartiles according to the age at first childbirth as follows: 13 to 21, 22 to 23, 24 to 25, and 26 to 44 years. We used odds ratios (ORs) and 95% confidence intervals (CIs) to address the relationships between age at first childbirth and age-related cataract with adjustments for confounders.

RESULTS

Mean participants' age and age at first childbirth were 64.4 and 23.6 years, respectively. The prevalence of any subtype of age-related cataract was 64.9%. Nuclear cataract prevalence was significantly higher in postmenopausal women with later age at first childbirth (24-25 and 26-44 years) compared with those with the earliest age at first childbirth (13-21 years): ORs (95% CIs) were 1.23 (1.05-1.45) and 1.24 (1.05-1.46), respectively. A significant linear trend across quintile was observed (P = 0.006). Age at first childbirth linearly 4% (OR 1.04, 95% CI 1.01-1.06) and 2% (OR 1.02, 95% CI 1.00-1.04) increased risk for nuclear and cortical cataract formation, respectively. The population-attributable fraction of nuclear cataract caused by the first childbirth at 24 years or later was 4.9% (95% CI 1.20%-8.59%, P = 0.009).

CONCLUSIONS

Later age of first childbirth was independently associated with higher risks of nuclear and cortical cataract in postmenopausal women. Further prospective studies are needed to elucidate the role of age at first childbirth in developing age-related cataract.

摘要

目的

尚无研究调查首次生育年龄对白内障形成的影响。本研究旨在确定首次生育年龄与绝经后女性年龄相关性白内障之间的关系。

方法

研究人群包括2008年至2012年韩国国家健康与营养检查调查中的7021名绝经后女性。参与者根据首次生育年龄分为四分位数，如下：13至21岁、22至23岁、24至25岁和26至44岁。我们使用优势比（OR）和95%置信区间（CI）来探讨首次生育年龄与年龄相关性白内障之间的关系，并对混杂因素进行了调整。

结果

参与者的平均年龄和首次生育年龄分别为64.4岁和23.6岁。年龄相关性白内障任何亚型的患病率为64.9%。与首次生育年龄最早（13至21岁）的绝经后女性相比，首次生育年龄较晚（24至25岁和26至44岁）的绝经后女性核性白内障患病率显著更高：OR（95%CI）分别为1.23（1.05至1.45）和1.24（1.05至1.46）。观察到五分位数间存在显著的线性趋势（P = 0.006）。首次生育年龄分别使核性和皮质性白内障形成风险线性增加4%（OR 1.04，95%CI 1.01至1.06）和2%（OR 1.02，95%CI 1.00至1.04）。24岁及以后首次生育导致的核性白内障的人群归因分数为4.9%（95%CI 1.20%至8.59%，P = 0.009）。