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分娩时产妇年龄对绝经后女性肥胖的影响:韩国一项基于全国人口的研究

Effect of Maternal Age at Childbirth on Obesity in Postmenopausal Women: A Nationwide Population-Based Study in Korea.

作者信息

We Ji-Sun, Han Kyungdo, Kwon Hyuk-Sang, Kil Kicheol

机构信息

From the Department of Obstetrics and Gynecology (J-SW, KK), Yeouido St. Mary's Hospital; Department of Medical Statistics (KH), College of Medicine; and Division of Endocrinology and Metabolism (H-SK), Department of Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

出版信息

Medicine (Baltimore). 2016 May;95(19):e3584. doi: 10.1097/MD.0000000000003584.

Abstract

The object of this study was to assess the obesity in postmenopausal women, according to age at childbirth.We analyzed the association between age at first childbirth, age at last childbirth, parity, and subject obesity status (general obesity; BMI >25 kg/m, nongeneral obesity; BMI ≤25 kg/m, abdominal obesity; waist circumference >85 cm, nonabdominal obesity; waist circumference ≤85 cm), using data from a nationwide population-based survey, the 2010 to 2012 Korean National Health and Nutrition Examination Survey. Data from a total of 4382 postmenopausal women were analyzed using multivariate regression analysis with complex survey design sampling. And, the subjects were subdivided into groups according to obesity or not. Age, smoking, alcohol consumption, exercise, education, income level, number of pregnancies, oral contraceptive uses, breast feeding experience were adjusted as the confounders.The prevalence of general obesity among Korean postmenopausal women was 37.08%. Women with general obesity and abdominal obesity were significantly younger at first childbirth compared with women with nongeneral obesity and no abdominal obesity (23.89 ± 0.1 vs. 23.22 ± 0.1, P <0.001). Age at first childbirth was inversely associated with obesity, while age at last childbirth was not associated with obesity or abdominal obesity. Women with a higher number of pregnancies were also more likely to have obesity and abdominal obesity. Age at first childbirth remained significantly associated with obesity, after adjusting for confounding factors.Obesity in postmenopausal women is associated with first childbirth at a young age, and higher parity. Further research is needed to clarify the association between obesity and reproductive characteristics.

摘要

本研究的目的是根据分娩年龄评估绝经后女性的肥胖情况。我们利用2010年至2012年韩国全国健康与营养检查调查这一基于全国人口的调查数据,分析了首次分娩年龄、末次分娩年龄、产次与受试者肥胖状况(一般肥胖;BMI>25kg/m²,非一般肥胖;BMI≤25kg/m²,腹型肥胖;腰围>85cm,非腹型肥胖;腰围≤85cm)之间的关联。使用复杂抽样调查设计的多元回归分析,对总共4382名绝经后女性的数据进行了分析。并且,根据是否肥胖将受试者分为不同组。将年龄、吸烟、饮酒、运动、教育程度、收入水平、怀孕次数、口服避孕药使用情况、母乳喂养经历作为混杂因素进行了调整。韩国绝经后女性中一般肥胖的患病率为37.08%。与非一般肥胖且无腹型肥胖的女性相比,一般肥胖和腹型肥胖的女性首次分娩时年龄显著更小(23.89±0.1岁对23.22±0.1岁,P<0.001)。首次分娩年龄与肥胖呈负相关,而末次分娩年龄与肥胖或腹型肥胖无关。怀孕次数较多的女性也更有可能患肥胖和腹型肥胖。在调整混杂因素后,首次分娩年龄仍与肥胖显著相关。绝经后女性的肥胖与年轻时首次分娩以及较高的产次有关。需要进一步研究以阐明肥胖与生殖特征之间的关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42dd/4902498/d6e71f931746/medi-95-e3584-g002.jpg

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