Kaingade Pankaj, Somasundaram Indumathi, Sharma Akshita, Patel Darshan, Marappagounder Dhanasekaran
1 Department of Biochemistry, P.D. Patel Institute of Applied Sciences, Charotar University of Science and Technology , Changa, Gujarat, India .
2 Department of Stem Cell and Regenerative Medicine, Centre for Interdisciplinary Research, D.Y. Patil University , Kolhapur, Maharashtra, India .
Breastfeed Med. 2017 Sep;12(7):446-449. doi: 10.1089/bfm.2017.0063. Epub 2017 Jun 22.
Whether the preterm mothers' mature milk retains the same cellular components as those in colostrum including stem-like cell, cell adhesion molecules, and immune cells.
A total of five preterm mothers were recruited for the study having an average age of 30.2 years and gestational age of 29.8 weeks from the Pristine Women's Hospital, Kolhapur. Colostrum milk was collected within 2-5 days and matured milk was collected 20-30 days after delivery from the same mothers.
Integral cellular components of 22 markers including stem cells, immune cells, and cell adhesion molecules were measured using flowcytometry.
Preterm mature milk was found to possess higher expressions of hematopoietic stem cells, mesenchymal stem-like cells, immune cells, few cell adhesion molecules, and side population cells than colostrum.
The increased level of these different cell components in mature milk may be important in the long-term preterm baby's health growth. Further similar research in a larger population of various gestational ages and lactation stages of preterm mothers is warranted to support these pilot findings.
早产母亲的成熟母乳是否保留了与初乳相同的细胞成分，包括干细胞、细胞黏附分子和免疫细胞。
从科尔哈布尔的普里斯汀妇女医院招募了5名早产母亲参与研究，她们的平均年龄为30.2岁，孕周为29.8周。在产后2至5天收集初乳，在同一母亲产后20至30天收集成熟乳。
使用流式细胞术测量包括干细胞、免疫细胞和细胞黏附分子在内的22种标志物的完整细胞成分。
发现早产成熟乳中造血干细胞、间充质干细胞样细胞、免疫细胞、少量细胞黏附分子和侧群细胞的表达高于初乳。
成熟乳中这些不同细胞成分水平的增加可能对早产婴儿的长期健康成长很重要。有必要在更多不同孕周和哺乳阶段的早产母亲群体中进行进一步类似研究，以支持这些初步发现。
