Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Polytechnic School of Abomey-Calavi, Department Human Biology Engineering, University of Abomey-Calavi, Abomey-Calavi, Benin.
Department of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, United States.
Front Immunol. 2022 Apr 5;13:849012. doi: 10.3389/fimmu.2022.849012. eCollection 2022.
Breastfeeding is associated with long-term wellbeing including low risks of infectious diseases and non-communicable diseases such as asthma, cancer, autoimmune diseases and obesity during childhood. In recent years, important advances have been made in understanding the human breast milk (HBM) composition. Breast milk components such as, non-immune and immune cells and bioactive molecules, namely, cytokines/chemokines, lipids, hormones, and enzymes reportedly play many roles in breastfed newborns and in mothers, by diseases protection and shaping the immune system of the newborn. Bioactive components in HBM are also involved in tolerance and appropriate inflammatory response of breastfed infants if necessary. This review summarizes the current literature on the relationship between mother and her infant through breast milk with regard to disease protection. We will shed some light on the mechanisms underlying the roles of breast milk components in the maintenance of health of both child and mother.
母乳喂养与长期健康有关，包括降低传染病和非传染性疾病（如哮喘、癌症、自身免疫性疾病和肥胖）的风险。近年来，人们对人乳（HBM）成分有了更深入的了解。母乳中的成分，如非免疫和免疫细胞以及生物活性分子，如细胞因子/趋化因子、脂质、激素和酶，据称在母乳喂养的新生儿和母亲中发挥着许多作用，通过疾病预防和塑造新生儿的免疫系统。HBM 中的生物活性成分也参与了母乳喂养婴儿在必要时的耐受和适当的炎症反应。这篇综述总结了目前关于母乳中母亲和婴儿通过母乳相互作用与疾病预防的相关文献。我们将探讨母乳成分在维持母婴健康方面的作用的潜在机制。
