Chae Unbin, Min Ju-Sik, Leem Hyun Hee, Lee Hyun-Shik, Lee Hong Jun, Lee Sang-Rae, Lee Dong-Seok
School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Republic of Korea.
Pharmacology. 2017;100(3-4):153-160. doi: 10.1159/000477814. Epub 2017 Jun 23.
Chrysophanic acid, or chrysophanol, is an anthraquinone found in Rheum palmatum, which was used in the preparation of oriental medicine in ancient China. The hippocampus plays a major role in controlling the activities of the short- and long-term memory. It is one of the major regions affected by excessive cell death in Alzheimer's disease. Therefore, neuronal cell-death modulation in the hippocampus is important for maintaining neuronal function. We investigated chrysophanol's effects on glutamate-induced hippocampal neuronal cell death. Chrysophanol reduced glutamate-induced cell death via suppression of proapoptotic factors and reactive oxygen species generation. Furthermore, it downregulated glutamate-induced mitochondrial fission by inhibiting dynamin-related protein 1 (Drp1) dephosphorylation. Thus, chrysophanol suppressed hippocampal neuronal cell death via inhibition of Drp1-dependent mitochondrial fission, and can be used as a therapeutic agent for treating neuronal cell death-mediated neurodegenerative diseases.
大黄酸，又称大黄酚，是一种存在于掌叶大黄中的蒽醌，在中国古代被用于制备传统中药。海马体在控制短期和长期记忆活动中起主要作用。它是阿尔茨海默病中受细胞过度死亡影响的主要区域之一。因此，海马体中神经元细胞死亡的调节对于维持神经元功能很重要。我们研究了大黄酚对谷氨酸诱导的海马神经元细胞死亡的影响。大黄酚通过抑制促凋亡因子和活性氧的产生来减少谷氨酸诱导的细胞死亡。此外，它通过抑制动力相关蛋白1（Drp1）的去磷酸化来下调谷氨酸诱导的线粒体分裂。因此，大黄酚通过抑制Drp1依赖性线粒体分裂来抑制海马神经元细胞死亡，可作为治疗神经元细胞死亡介导的神经退行性疾病的治疗剂。
