Li Xun, Chu Shifeng, Liu Yinjiao, Chen Naihong
College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Evid Based Complement Alternat Med. 2019 May 16;2019:3790728. doi: 10.1155/2019/3790728. eCollection 2019.
Rhubarb is a well-known traditional Chinese medicine; it has been used in China for thousands of years. Rhubarb anthraquinones are the major medicinal ingredients derived from rhubarb including emodin, aloe-emodin, chrysophanol, rhein, physcion, and danthron. These different anthraquinone derivatives alone or in combination play a therapeutic role in central nervous system diseases (CNSD), such as cerebral ischemic stroke, intracerebral hemorrhage, traumatic brain injury, brain tumor, Alzheimer's disease, depression, and others. We review the experimental studies on these six anthraquinones in the treatment of CNSD by consulting literature published in the last 20 years in PubMed and then give a future perspective on it. In the end of this paper some deficiencies related to these studies also have been pointed out.
大黄是一种著名的传统中药，在中国已使用了数千年。大黄蒽醌是从大黄中提取的主要药用成分，包括大黄素、芦荟大黄素、 Chrysophanol、大黄酸、大黄酚和决明蒽醌。这些不同的蒽醌衍生物单独或联合使用，在中枢神经系统疾病（CNSD）如脑缺血性中风、脑出血、创伤性脑损伤、脑肿瘤、阿尔茨海默病、抑郁症等疾病中发挥治疗作用。我们通过查阅过去20年在PubMed上发表的文献，综述了这六种蒽醌在治疗CNSD方面的实验研究，并对其未来进行了展望。本文末尾还指出了这些研究存在的一些不足之处。
