Wang Xintong, Cheng Fangyuan, Zhong Diansheng, Zhang Lisha, Meng Fanlu, Shao Yi, Yu Tao
Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Zhongguo Fei Ai Za Zhi. 2017 Jun 20;20(6):395-401. doi: 10.3779/j.issn.1009-3419.2017.06.05.
Malignant pleural effusion (MPE) is due tumor which arises from the mesothelium or metastases from tumor origniating other sites. Generally, the prognosis of MPE is poor, in the premise of reducing the pain of patients, as soon as possible make clear the property of pleural effusion and cause of the disesease, rightly and quickly, providing effective information for subsequent treatment.
The cell block of 103 patients by using natural sedimentation or plasma coagulation method combined with HE staining and immunohistochemical staining method maked clear diagnosis and compared with other methods.
90 patients were diagnosed by cell block section from 103 patients who had MPE (diagnostic rate 87.4%); 32 cases were diagnosed by cell block section only, 74 cases pointed out that the pathological type , 23 cases even pointed out the primary lesions; 71 cases examined other invasive methods at the same time, the diagnostic rate was 87.3% and 81.7%; the detection rate of cell block section and cytological smear in detecting malignant tumor cells was 86.7%and 44.0% respectively.
Cell block can not only increase the diagnosis, in contrast to cytological smear, and own the same diagnostic rate compared with other invasive methods, but also can confirm pathological type and primary lesion; especially, for other invasive methods, cell block method is a preferable complementary method, and that cell block method maybe the only way for some patients.
恶性胸腔积液（MPE）是由间皮瘤或其他部位肿瘤转移引起的。一般来说，MPE的预后较差，在减轻患者痛苦的前提下，尽快明确胸腔积液的性质和疾病原因，正确、迅速地为后续治疗提供有效信息。
对103例患者的细胞块采用自然沉降或血浆凝固法结合HE染色和免疫组化染色法进行明确诊断，并与其他方法进行比较。
103例MPE患者中，90例通过细胞块切片确诊（诊断率87.4%）；仅通过细胞块切片确诊32例，指出病理类型74例，甚至指出原发灶23例；71例同时采用其他侵入性方法检查，诊断率分别为87.3%和81.7%；细胞块切片和细胞学涂片检测恶性肿瘤细胞的检出率分别为86.7%和44.0%。
细胞块不仅能提高诊断率，与细胞学涂片相比，与其他侵入性方法具有相同的诊断率，还能明确病理类型和原发灶；特别是对于其他侵入性方法，细胞块法是一种较好的补充方法，对于一些患者来说，细胞块法可能是唯一的方法。
