Hagen M, Filosa M F, Youson J H
Comp Biochem Physiol A Comp Physiol. 1985;82(1):207-10. doi: 10.1016/0300-9629(85)90727-3.
Adult lamprey were shown to produce antigen-specific antibody in response to weekly injections of human O-type erythrocytes ('O'-RBC) at both 17 degrees C and 9 degrees C. At the higher temperature, high titre antisera were produced earlier and at a faster rate than in animals kept at 9 degrees C. Lamprey kept at 9 degrees C, after a long lag period, eventually produced titres comparable to those obtained at 17 degrees C. Lamprey immunized and maintained at 9 degrees C were capable of producing high titres of antibody in response to second injection of antigen after the primary response titre had declined.
研究表明，成年七鳃鳗在17摄氏度和9摄氏度的环境下，每周注射人O型红细胞（“O”-RBC）后会产生抗原特异性抗体。在较高温度下，与饲养在9摄氏度的动物相比，产生高滴度抗血清的时间更早，速度更快。饲养在9摄氏度的七鳃鳗，经过较长的延迟期后，最终产生的滴度与17摄氏度时相当。在9摄氏度下免疫并饲养的七鳃鳗，在初次反应滴度下降后，再次注射抗原时能够产生高滴度抗体。
