Zhu Xiaosong, Jiang Xiaoyan, Li Ang, Sun Yueyue, Liu Yan, Sun Xiao, Feng Xiuli, Li Siying, Zhao Zhongxi
School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
Biochem Biophys Res Commun. 2017 Sep 23;491(3):821-826. doi: 10.1016/j.bbrc.2017.06.107. Epub 2017 Jun 19.
Gastric cancer remains as a common lethal malignancy worldwide. Developing novel anti-gastric cancer drugs with minimal side effects is necessary to address this public health issue. S-allylmercaptocysteine (SAMC), one of the water-soluble organosulfur garlic derivatives, has been demonstrated as a suppressive agent against tumors. In this study, we examined the effect of SAMC on human gastric carcinoma growth in vivo and explored the underlying mechanism. Human gastric cancer SGC-7901 cells were inoculated subcutaneously in BALB/c nude mice. When xenograft tumors reached about 100 mm, mice were treated with SAMC for 30 days. We observed that SAMC administration in mice effectively delayed the growth of SGC-7901 xenografts without signs of toxicity. TUNEL staining confirmed that the tumors from SAMC-treated mice exhibited a markedly higher apoptotic index. Mechanistic studies suggested that this activity may arise from its effects on the caspase activation and modulation of MAPK and PI3K/Akt signaling pathways. Taken together, these data support development of SAMC as a potential agent for gastric cancer therapy.
胃癌仍然是全球常见的致命恶性肿瘤。开发副作用最小的新型抗胃癌药物对于解决这一公共卫生问题很有必要。S-烯丙基巯基半胱氨酸（SAMC）是一种水溶性有机硫大蒜衍生物，已被证明是一种肿瘤抑制剂。在本研究中，我们检测了SAMC对人胃癌体内生长的影响，并探讨了其潜在机制。将人胃癌SGC-7901细胞皮下接种于BALB/c裸鼠。当异种移植瘤长到约100mm时，用SAMC处理小鼠30天。我们观察到，给小鼠施用SAMC可有效延缓SGC-7901异种移植瘤的生长，且无毒性迹象。TUNEL染色证实，SAMC处理小鼠的肿瘤凋亡指数明显更高。机制研究表明，这种活性可能源于其对caspase激活以及MAPK和PI3K/Akt信号通路的调节作用。综上所述，这些数据支持将SAMC开发为一种潜在的胃癌治疗药物。
