Beaulieu J F, Calvert R
Comp Biochem Physiol A Comp Physiol. 1985;82(1):91-5. doi: 10.1016/0300-9629(85)90709-1.
The effects of glucocorticoids on the maturation of the fetal small intestinal mucosa have been studied using duodenal explants resected at 17 days of gestation and cultured in a serum-free medium in the presence or absence of dexamethasone (30-300 ng/ml). Dexamethasone (a) increases specifically alkaline phosphatase, maltase, trehalase and sucrase activities and (b) allows an accumulation of goblet cells along the villi at a faster rate than that occurring in utero. These results indicate that glucocorticoids influence directly the differentiation of absorptive cells and goblet cells in the small intestine during the fetal period.
利用妊娠17天时切除的十二指肠外植体，在有或没有地塞米松（30 - 300 ng/ml）的无血清培养基中培养，研究了糖皮质激素对胎儿小肠黏膜成熟的影响。地塞米松（a）特异性增加碱性磷酸酶、麦芽糖酶、海藻糖酶和蔗糖酶的活性，并且（b）使杯状细胞沿绒毛的积累速度比子宫内发生的速度更快。这些结果表明，糖皮质激素在胎儿期直接影响小肠吸收细胞和杯状细胞的分化。
